Enzyme Engineering and Structural Biology

The Enzyme Engineering and Structural Biology group develops enzyme biocatalysts for the industrial production of natural products such as aromas, fragrances, dyes and pharmaceuticals, with an emphasis on glycosylation.

The Enzyme Engineering and Structural Biology develops enzymes for biocatalysis, using structural biology and protein chemistry as our primary tools. We strive to take a modern approach to these well-established disciplines, with multidimensional experimental setup and increased throughput. We are particularly interested in enzymatic glycosylation of natural products, as a tool to control solubility, volatility, stability, compartmentalization, and toxicity. For this, we focus on plant enzymes of the glycosyltransferase class. We work to elucidate glycosyltransferase structure-function relationships governing specificity, turn-over rate and stability.The group’s primary techniques are X-ray crystallography, HPLC, and machine learning.


If you are interested in joining us, please don’t hesitate to reach out.  



Ditte Hededam Welner
Senior Researcher & Group Leader
DTU Biosustain
+45 93 51 34 98