The small molecules encoded by these biosynthetic gene clusters often have various bioactivities including anti-microbial, anti-cancer, anthelmintic and others. Therefore, they are lead compounds for many drugs like antibiotics.
antiSMASH is the most widely used tool for these genome mining approaches. Since its initial release in 2011, more than 160,000 analyses have been performed on the public antiSMASH service, which recently was moved to DTU Biosustain.
AntiSmash Links:
References:
- Weber, T., Blin, K., Duddela, S., Krug, D., Kim, H.U., Bruccoleri, R., Lee, S.Y., Fischbach, M.A., Müller, R., Wohlleben, W., Breitling, R., Takano, E., Medema, M.H., (2015) antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters. Nucleic Acids Res. 43, W237-W243.
- Blin, K., Kazempour, D., Wohlleben, W., Weber, T., (2014) Improved lanthipeptide detection and prediction for antiSMASH. PLoS ONE 9, e89420. (Open Access)
- Blin, K., Medema, M.H., Kazempour, D., Fischbach, M., Breitling, R., Takano, E., Weber, T., (2013) antiSMASH 2.0 – a versatile platform for genome mining of secondary metabolite producers. Nucleic Acids Res. 41, W204-W212. (Open Access)
- Medema, M.H., Blin, K., Cimermancic, P., de Jager, V., Zakrzewski, P., Fischbach, M.A., Weber, T., Takano, E., Breitling, R., (2011) antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res. 39, W339-W346. (Open Access)
Contact: Tilmann Weber