Publications

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2020
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Adaptation of hydroxymethylbutenyl diphosphate reductase enables volatile isoprenoid production

Bongers, Mareike ; Perez-Gil, Jordi ; Hodson, Mark P. ; Schrübbers, Lars ; Wulff, Tune ; Sommer, Morten Oa ; Nielsen, Lars K. ; Vickers, Claudia E.
in: eLife, vol: 9

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.7554/elife.48685

2019
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Combined Rapid Injection NMR and Simulation Approach to Probe Redox-Dependent Pathway Control in Living Cells

Jensen, Pernille Rose ; Matos, Marta ; Sonnenschein, Nikolaus ; Meier, Sebastian
in: Analytical Chemistry, vol: 91, issue: 8, pages: 5395-5402

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1021/acs.analchem.9b00660

 

Concomitant consumption of glucose and lactate: A novel batch production process for CHO cells

Martínez-Monge, I. ; Comas, P. ; Triquell, J. ; Casablancas, A. ; Lecina, M. ; Paredes, C.J. ; Cairó, J.J.
in: Biochemical Engineering Journal, vol: 151

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.bej.2019.107358

 

New developments in online OUR monitoring and its application to animal cell cultures

Martínez-Monge, I ; Roman, R. ; Comas, P. ; Fontova, A. ; Lecina, M. ; Casablancas, A. ; Cairó, J J
in: Applied Microbiology and Biotechnology, vol: 103, issue: 17, pages: 6903-6917

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1007/s00253-019-09989-4

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Stoichiometric gene-to-reaction associations enhance model-driven analysis performance: Metabolic response to chronic exposure to Aldrin in prostate cancer

Marín de Mas, Igor Batolomé ; Torrents, Laura ; Bedia, Carmen ; Nielsen, Lars K ; Cascante, Marta ; Tauler, Romà
in: BMC Genomics, vol: 20, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1186/s12864-019-5979-4

2018
 

Advances in analytical tools for high throughput strain engineering

Marcellin, Esteban ; Nielsen, Lars Keld
in: Current Opinion in Biotechnology, vol: 54, pages: 33-40

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.copbio.2018.01.027

 

An Expanded Heterologous GAL Promoter Collection for Diauxie-Inducible Expression in Saccharomyces cerevisiae

Peng, Bingyin ; Wood, Rebecca J. ; Nielsen, Lars K. ; Vickers, Claudia E.
in: A C S Synthetic Biology, vol: 7, issue: 2, pages: 748-751

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1021/acssynbio.7b00355

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Engineered protein degradation of farnesyl pyrophosphate synthase is an effective regulatory mechanism to increase monoterpene production in Saccharomyces cerevisiae

Peng, Bingyin ; Nielsen, Lars K. ; Kampranis, Sotirios C ; Vickers, Claudia E
in: Metabolic Engineering, vol: 47, pages: 83-93

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.ymben.2018.02.005

 

From reconstruction to C4 metabolic engineering: A case study for overproduction of polyhydroxybutyrate in bioenergy grasses

Gomes de Oliveira Dal'Molin, Cristiana ; Quek, Lake-Ee ; Saa, Pedro A. ; Palfreyman, Robin ; Nielsen, Lars Keld
in: Plant Science, vol: 273, pages: 50-60

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.plantsci.2018.03.027

 

Improving culture performance and antibody production in CHO cell culture processes by reducing the Warburg effect

Buchsteiner, Maria ; Quek, Lake-Ee ; Gray, Peter ; Nielsen, Lars K.
in: Biotechnology and Bioengineering, vol: 115, issue: 9, pages: 2315-2327

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1002/bit.26724

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Mass Action Stoichiometric. Simulation for Cell Factory Design

Matos, Marta R. A.

Type: Ph.D. thesis

Status: Published     |    Year: 2018

 

Minimizing Clonal Variation during Mammalian Cell Line Engineering for Improved Systems Biology Data Generation

Grav, Lise Marie ; Sergeeva, Daria ; Lee, Jae Seong ; Marín de Mas, Igor ; Lewis, Nathan E. ; Andersen, Mikael Rørdam ; Nielsen, Lars Keld ; Min Lee, Gyun ; Kildegaard, Helene Faustrup
in: A C S Synthetic Biology, vol: 7, issue: 9, pages: 2148-2159

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1021/acssynbio.8b00140

 

Multiomic Data Integration and Analysis via Model-Driven Approaches

Marín de Mas, Igor Batolomé
in: Comprehensive Analytical Chemistry, vol: 82, pages: 447-476

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/bs.coac.2018.07.005

 

RNA-Seq Highlights High Clonal Variation in Monoclonal Antibody Producing CHO Cells

Orellana, Camila A. ; Marcellin, Esteban ; Palfreyman, Robin W. ; Munro, Trent P. ; Gray, Peter P. ; Nielsen, Lars K.
in: Biotechnology Journal, vol: 13, issue: 3

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1002/biot.201700231

 

Toward Synthetic Biology Strategies for Adipic Acid Production: An in Silico Tool for Combined Thermodynamics and Stoichiometric Analysis of Metabolic Networks

Averesch, Nils J. H. ; Martínez, Verónica S. ; Nielsen, Lars K. ; Krömer, Jens O.
in: A C S Synthetic Biology, vol: 7, issue: 2, pages: 490-509

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1021/acssynbio.7b00304

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Universal Alternative Splicing of Noncoding Exons

Deveson, Ira W ; Brunck, Marion E ; Blackburn, James ; Tseng, Elizabeth ; Hon, Ting ; Clark, Tyson A ; Clark, Michael B ; Crawford, Joanna ; Dinger, Marcel E ; Nielsen, Lars K ; Mattick, John S ; Mercer, Tim R
in: Cell Systems, vol: 6, issue: 2, pages: 153-155

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.cels.2017.12.005

2017
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Formulation, construction and analysis of kinetic models of metabolism: A review of modelling frameworks

Saa, Pedro A. ; Nielsen, Lars K.
in: Biotechnology Advances, vol: 35, issue: 8, pages: 981-1003

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1016/j.biotechadv.2017.09.005

2014
 

A kinetic model of thiamine biosynthesis in Escherichia coli

Matos, Marta ; Herrgard, Markus ; Andersen, Mikael Rørdam ; Sonnenschein, Nikolaus
part of: Abstract Book - DTU Sustain Conference 2014, 2014, Technical University of Denmark, Kgs. Lyngby
Presented at:
DTU Sustain Conference 2014

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published     |    Year: 2014