Key publications

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters. / Weber, Tilmann; Blin, Kai; Duddela, Srikanth; Krug, Daniel; Kim, Hyun Uk; Bruccoleri, Robert; Lee, Sang Yup; Fischbach, Michael A.; Müller, Rolf; Wohlleben, Wolfgang, (2015) Nucleic Acids Research, Vol. 43, No. W1, 05.2015, p. W237-W243.

CRISPR-Cas9 Based Engineering of Actinomycetal Genomes. / Tong, Yaojun; Charusanti, Pep; Zhang, Lixin; Weber, Tilmann; Lee, Sang Yup (2015) A C S Synthetic Biology

How to set up collaborations between academia and industrial biotech companies. / Pronk, Jack T.; Lee, Sang Yup; Lievense, Jeff; Pierce, John; Palsson, Bernhard; Uhlén, Mathias; Nielsen, Jens (2015) Nature Biotechnology, Vol. 33, No. 3, 2015, p. 237-240.

A systems approach to traditional oriental medicine. / Kim, Hyun Uk; Ryu, Jae Yong; Lee, Jong Ok; Lee, Sang Yup (2015) Nature Biotechnology

Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites. / Hwang, K.S., Kim, H.U., Charusanti, P., Palsson, B.O., Lee, S.Y., (2014) Biotechnol. Adv. 32, 255-268.

In silico tools for the analysis of antibiotic biosynthetic pathways. / Weber, T., (2014)  Int. J. Med. Microbiol., 304 (3-4):230-235..

Engineering synergy in biotechnology. / Nielsen, J., Fussenegger, M., Keasling, J., Lee, S.Y., Liao, J.C., Prather, K., and Palsson, B. (2014). Nat. Chem. Biol. 10, 319-322.

Effects of introducing heterologous pathways on microbial metabolism with respect to metabolic optimality. / Kim, H.U., Kim, B., Seung, D., Lee, S.Y. (2014)  Biotechnology and Bioprocess Engineering. 19, 660-667.


Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes. / Weber, T., Charusanti P., Musiol-Kroll, E.M., Jiang, X., Tong, Y., Kim, H.U., and Lee, S.Y. (2015) Trends Biotechnol. 33:15-26. - Journal cover paper