Bacterial Synthetic Biology

The Bacterial Synthetic Biology section focuses on the development of new approaches and technologies for accelerating cell factory development and stabilising favourable production phenotypes.

The section develops synthetic networks that sense intracellular metabolites and control cellular processes. These systems are deployed to discover novel genes and pathways as well as to optimise cell factories for increased chemical production. Initially, the section's work is focused on developing proof-of-concept for these principles. However, the technology will gradually be deployed towards the development of commercially relevant cell factories.

In addition to this work, the section conducts genome wide studies on the factors influencing phenotypic stability in E. coli. The section is interested in understanding the pathways by which cells express heterologous pathways or how specific enzymatic activities can destabilise high yielding production phenotypes. The section uses this information to construct more robust production strains.

The Bacterial Synthetic Biology section is located at The Novo Nordisk Foundation Center for Biosustainability, DTU Biosustain and it is headed Scientific Director, Professor Morten Sommer.

Contact

Morten Otto Alexander Sommer
Scientific Director
DTU Biosustain
+45 21 51 83 40