Publications - DTU Biosustain

Adaptive laboratory evolution reveals general and specific chemical tolerance mechanisms and enhances biochemical production

Lennen, Rebecca M. ; Jensen, Kristian ; Mohammed, Elsayed T. ; Malla, Sailesh ; Börner, Rosa A. ; Chekina, Ksenia ; Özdemir, Emre ; Bonde, Ida ; Koza, Anna ; Maury, Jérôme ; Pedersen, Lasse E. ; Schöning, Lars Y. ; Sonnenschein, Nikolaus ; Palsson, Bernhard O. ; Sommer, Morten O. A. ; Feist, Adam M. ; Nielsen, Alex T. ; Herrgård, Markus J.
in: bioRxiv

Type: Journal article

Status: Submitted | Year: 2021 | DOI: https://doi.org/10.1101/634105

Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture

Ha, Tae Kwang ; Kim, Dongil ; Kim, Che Lin ; Grav, Lise Marie ; Lee, Gyun Min
in: Biotechnology Advances

Type: Review (Peer reviewed)

Status: Accepted/In press | Year: 2021 | DOI: https://doi.org/10.1016/j.biotechadv.2021.107831

Bacillus velezensis stimulates resident rhizosphere Pseudomonas stutzeri for plant health through metabolic interactions

Sun, Xinli ; Xu, Zhihui ; Xie, Jiyu ; Hesselberg-Thomsen, Viktor ; Tan, Taimeng ; Zheng, Daoyue ; Strube, Mikael L. ; Dragoš, Anna ; Shen, Qirong ; Zhang, Ruifu ; Kovács, Ákos T.
in: ISME Journal

Type: Journal article (Peer reviewed)

Status: Accepted/In press | Year: 2021 | DOI: https://doi.org/10.1038/s41396-021-01125-3

Metabolic Modeling and Omics Data Integration: A Systems Biology Approach to Food Science

Marín de Mas, Igor Batolomé ; de Leeuw, Marina ; Ghaffari Nouran, Pouyan ; Nielsen, Lars Keld
part of: Comprehensive Foodomics, pages: 396-413, 2021

Type: Book chapter (Peer reviewed)

Status: Published | Year: 2021

multiTFA: a python package for multi-variate thermodynamics-based flux analysis

Mahamkali, Vishnuvardhan ; McCubbin, Tim ; Beber, Moritz Emanuel ; Noor, Elad ; Marcellin, Esteban ; Nielsen, Lars Keld
in: Bioinformatics

Type: Journal article (Peer reviewed)

Status: Accepted/In press | Year: 2021 | DOI: https://doi.org/10.1093/bioinformatics/btab151

‘Omics driven discoveries of gene targets for apoptosis attenuation in CHO cells

Orellana, Camila A. ; Martínez, Verónica S. ; MacDonald, Michael A. ; Henry, Matthew N. ; Gillard, Marianne ; Gray, Peter P. ; Nielsen, Lars K. ; Mahler, Stephen ; Marcellin, Esteban
in: Biotechnology and Bioengineering, vol: 118, issue: 1, pages: 481-490

Type: Journal article (Peer reviewed)

Status: Published | Year: 2021 | DOI: https://doi.org/10.1002/bit.27548

The Effect of the Expression of the Antiapoptotic BHRF1 Gene on the Metabolic Behavior of a Hybridoma Cell Line

Martínez-Monge, Iván ; Comas, Pere ; Catalán-Tatjer, David ; Prat, Jordi ; Casablancas, Antoni ; Paredes, Carlos ; Lecina, Martí ; Cairó, Jordi Joan
in: Applied Sciences, vol: 11, issue: 14

Type: Journal article (Peer reviewed)

Status: Published | Year: 2021 | DOI: https://doi.org/10.3390/app11146258

Adaptation of hydroxymethylbutenyl diphosphate reductase enables volatile isoprenoid production

Bongers, Mareike ; Perez-Gil, Jordi ; Hodson, Mark P. ; Schrübbers, Lars ; Wulff, Tune ; Sommer, Morten Oa ; Nielsen, Lars K. ; Vickers, Claudia E.
in: eLife, vol: 9

Type: Journal article (Peer reviewed)

Status: Published | Year: 2020 | DOI: https://doi.org/10.7554/elife.48685

Attenuating apoptosis in Chinese hamster ovary cells for improved biopharmaceutical production

Henry, Matthew N. ; MacDonald, Michael A. ; Orellana, Camila A. ; Gray, Peter P. ; Gillard, Marianne ; Baker, Kym ; Nielsen, Lars K. ; Marcellin, Esteban ; Mahler, Stephen ; Martínez, Verónica S.
in: Biotechnology and Bioengineering, vol: 17, issue: 4, pages: 1187-1203

Type: Journal article (Peer reviewed)

Status: Published | Year: 2020 | DOI: https://doi.org/10.1002/bit.27269

Fungal secretome profile categorization of CAZymes by function and family corresponds to fungal phylogeny and taxonomy: Example Aspergillus and Penicillium

Barrett, Kristian ; Jensen, Kristian ; Meyer, Anne S. ; Frisvad, Jens Christian ; Lange, Lene
in: Scientific Reports, vol: 10, issue: 1

Type: Journal article (Peer reviewed)

Status: Published | Year: 2020 | DOI: https://doi.org/10.1038/s41598-020-61907-1