Publications - DTU Biosustain

Adaptive laboratory evolution reveals general and specific chemical tolerance mechanisms and enhances biochemical production

Lennen, Rebecca M. ; Jensen, Kristian ; Mohammed, Elsayed T. ; Malla, Sailesh ; Börner, Rosa A. ; Chekina, Ksenia ; Özdemir, Emre ; Bonde, Ida ; Koza, Anna ; Maury, Jérôme ; Pedersen, Lasse E. ; Schöning, Lars Y. ; Sonnenschein, Nikolaus ; Palsson, Bernhard O. ; Sommer, Morten O. A. ; Feist, Adam M. ; Nielsen, Alex T. ; Herrgård, Markus J.
in: bioRxiv

Type: Journal article

Status: Submitted | Year: 2022 | DOI: https://doi.org/10.1101/634105

A Genome-Scale Metabolic Model of Methanoperedens nitroreducens: Assessing Bioenergetics and Thermodynamic Feasibility

He, Bingqing ; Cai, Chen ; McCubbin, Tim ; Muriel, Jorge Carrasco ; Sonnenschein, Nikolaus ; Hu, Shihu ; Yuan, Zhiguo ; Marcellin, Esteban
in: Metabolites, vol: 12, issue: 4

Type: Journal article (Peer reviewed)

Status: Published | Year: 2022 | DOI: https://doi.org/10.3390/metabo12040314

Factors affecting the quality of therapeutic proteins in recombinant Chinese hamster ovary cell culture

Ha, Tae Kwang ; Kim, Dongil ; Kim, Che Lin ; Grav, Lise Marie ; Lee, Gyun Min
in: Biotechnology Advances, vol: 54

Type: Review (Peer reviewed)

Status: Published | Year: 2022 | DOI: https://doi.org/10.1016/j.biotechadv.2021.107831

Multi-omic characterisation of Streptomyces hygroscopicus NRRL 30439: detailed assessment of its secondary metabolic potential

Barry, Craig P. ; Gillane, Rosemary ; Talbo, Gert H. ; Plan, Manual ; Palfreyman, Robin ; Haber-Stuk, Andrea K. ; Power, John ; Nielsen, Lars K. ; Marcellin, Esteban
in: Molecular Omics

Type: Journal article (Peer reviewed)

Status: Accepted/In press | Year: 2022 | DOI: https://doi.org/10.1039/d1mo00150g

Perfusion culture of Chinese Hamster Ovary cells for bioprocessing applications

MacDonald, Michael A. ; Nöbel, Matthias ; Roche Recinos, Dinora ; Martínez, Verónica S. ; Schulz, Benjamin L. ; Howard, Christopher B. ; Baker, Kym ; Shave, Evan ; Lee, Yih Yean ; Marcellin, Esteban ; Mahler, Stephen ; Nielsen, Lars Keld ; Munro, Trent
in: Critical Reviews in Biotechnology

Type: Review (Peer reviewed)

Status: Accepted/In press | Year: 2022 | DOI: https://doi.org/10.1080/07388551.2021.1998821

Soft-sensors application for automated feeding control in high-throughput mammalian cell cultures

Martínez-Monge, I. ; Martínez, C. ; Decker, M. ; Udugama, I. A. ; Marín de Mas, I. ; Gernaey, K. V. ; Nielsen, L. K.
in: Biotechnology and Bioengineering, vol: 119, issue: 4, pages: 1077-1090

Type: Journal article (Peer reviewed)

Status: Published | Year: 2022 | DOI: https://doi.org/10.1002/bit.28032

2.28 - Metabolic Modeling and Omics Data Integration: A Systems Biology Approach to Food Science

Marín de Mas, Igor ; de Leeuw, Marina ; Ghaffari, Pouyan ; Nielsen, Lars K.
in: Comprehensive Foodomics, vol: 2, pages: 396-417

Type: Journal article (Peer reviewed)

Status: Published | Year: 2021 | DOI: https://doi.org/10.1016/B978-0-08-100596-5.22914-4

Metabolic Modeling and Omics Data Integration: A Systems Biology Approach to Food Science

Marín de Mas, Igor Batolomé ; de Leeuw, Marina ; Ghaffari Nouran, Pouyan ; Nielsen, Lars Keld
part of: Comprehensive Foodomics, pages: 396-413, 2021

Type: Book chapter (Peer reviewed)

Status: Published | Year: 2021

Model-guided dynamic control of essential metabolic nodes boosts acetyl-coenzyme A–dependent bioproduction in rewired Pseudomonas putida

Kozaeva, Ekaterina ; Volkova, Svetlana ; Matos, Marta R.A. ; Mezzina, Mariela P. ; Wulff, Tune ; Volke, Daniel C. ; Nielsen, Lars K. ; Nikel, Pablo I.
in: Metabolic Engineering, vol: 67, pages: 373-386

Type: Journal article (Peer reviewed)

Status: Published | Year: 2021 | DOI: https://doi.org/10.1016/j.ymben.2021.07.014

Multi-omics study of planobispora rosea, producer of the thiopeptide antibiotic GE2270A

Carratore, Francesco Del ; Iorio, Marianna ; Pérez-Bonilla, Mercedes ; Schmidt, Kamila ; Pérez-Redondo, Rosario ; Sosio, Margherita ; Macdonald, Sandy J. ; Gyulev, Ivan S. ; Tsigkinopoulou, Areti ; Thomas, Gavin H. ; Genilloud, Olga ; Rodríguez-García, Antonio ; Donadio, Stefano ; Breitling, Rainer ; Takano, Eriko
in: mSystems, vol: 6, issue: 3

Type: Journal article (Peer reviewed)

Status: Published | Year: 2021 | DOI: https://doi.org/10.1128/mSystems.00341-21