All publications - DTU Biosustain

Biosynthesis of the Azoxy Compound Azodyrecin from Streptomyces mirabilis P8-A2

Maleckis, Matiss ; Wibowo, Mario ; Gren, Tetiana ; Jarmusch, Scott A ; Sterndorff, Eva B. ; Booth, Thomas ; Henriksen, Nathalie N. S. E. ; Whitford, Christopher M. ; Jiang, Xinglin ; Jørgensen, Tue S. ; Ding, Ling ; Weber, Tilmann
in: ACS chemical biology, vol: 19, issue: 3, pages: 641-653

Type: Journal article (Peer reviewed)

Status: Published | Year: 2024 | DOI: https://doi.org/10.1021/acschembio.3c00632

Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus

Torres Salazar, Benjamin O. ; Dema, Taulant ; Schilling, Nadine A. ; Janek, Daniela ; Bornikoel, Jan ; Berscheid, Anne ; Elsherbini, Ahmed M.A. ; Krauss, Sophia ; Jaag, Simon J. ; Lämmerhofer, Michael ; Li, Min ; Alqahtani, Norah ; Horsburgh, Malcolm J. ; Weber, Tilmann ; Beltrán-Beleña, José Manuel ; Brötz-Oesterhelt, Heike ; Grond, Stephanie ; Krismer, Bernhard ; Peschel, Andreas
in: Nature Microbiology, vol: 9, issue: 1, pages: 200-213

Type: Journal article (Peer reviewed)

Status: Published | Year: 2024 | DOI: https://doi.org/10.1038/s41564-023-01544-2

Dilarmycins A-C, Calcium-Dependent Lipopeptide Antibiotics with a Non-canonical Ca(2+)-Binding Motif

Fernández-Pastor, Ignacio ; Ortiz-López, Francisco Javier ; Oves-Costales, Daniel ; Martín, Jesús ; Sánchez, Pilar ; Melguizo, Ángeles ; Reyes Gonzalez, Fernando ; Weber, Tilmann ; Genilloud, Olga
in: Organic Letters, vol: 26, issue: 7, pages: 1343–1347

Type: Journal article (Peer reviewed)

Status: Published | Year: 2024 | DOI: https://doi.org/10.1021/acs.orglett.3c04195

Pepticinnamins N, O, and P, Nonribosomal Peptides from the Soil-Derived Streptomyces mirabilis P8-A2

Mohamed, Manar Magdy Mahmoud ; Abboud, Maria Mahmoud ; Maleckis, Matiss ; Souza, Luciano D. O. ; Moreira, José M. A. ; Gotfredsen, Charlotte H. ; Weber, Tilmann ; Ding, Ling
in: Journal of Natural Products

Type: Journal article (Peer reviewed)

Status: Accepted/In press | Year: 2024 | DOI: https://doi.org/10.1021/acs.jnatprod.4c00029

teemi: An open-source literate programming approach for iterative design-build-test-learn cycles in bioengineering

Petersen, Søren D. ; Levassor, Lucas ; Pedersen, Christine M. ; Madsen, Jan ; Hansen, Lea G. ; Zhang, Jie ; Haidar, Ahmad K. ; Frandsen, Rasmus J. N. ; Keasling, Jay D. ; Weber, Tilmann ; Sonnenschein, Nikolaus ; K. Jensen, Michael
in: PLOS Computational Biology, vol: 20, issue: 3

Type: Journal article (Peer reviewed)

Status: Published | Year: 2024 | DOI: https://doi.org/10.1371/journal.pcbi.1011929

The antiSMASH database version 4: additional genomes and BGCs, new sequence-based searches and more

Blin, Kai ; Shaw, Simon ; Medema, Marnix H. ; Weber, Tilmann
in: Nucleic Acids Research, vol: 52, issue: D1, pages: D586–D589

Type: Journal article (Peer reviewed)

Status: Published | Year: 2024 | DOI: https://doi.org/10.1093/nar/gkad984

1000+ New Complete Genomes Aid Discovery Of Natural Products

Jørgensen, Tue Sparholt ; Mohite, Omkar Satyavan ; Sterndorff, Eva Baggesgaard ; Arévalo, María Álvarez ; Blin, Kai ; Booth, Thomas ; Charusanti, Pep ; Faurdal, David Lokjær ; Hansen, Troels Østergaard ; Mourched, Anna-Sophie ; Phaneuf, Patrick Victor ; Palsson, Bernhard ; Weber, Tilmann
part of: The Danish Microbiological Society Annual Congress 2023, pages: 82-82, 2023
Presented at: The Danish Microbiological Society Annual Congress 2023

Type: Conference abstract in proceedings (Peer reviewed)

Status: Published | Year: 2023

antiSMASH 7.0

Blin, Kai ; Shaw, Simon ; Augustijn, Hannah E ; Reitz, Zachary L ; Biermann, Friederike ; Alanjary, Mohammad ; Fetter, Artem ; Terlouw, Barbara R ; Metcalf, William W ; Helfrich, Eric J N ; van Wezel, Gilles P ; Medema, Marnix H ; Weber, Tilmann
in: Nucleic Acids Research, vol: 51, pages: 5

Type: Journal article (Peer reviewed)

Status: Published | Year: 2023 | DOI: https://doi.org/10.1093/nar/gkad344

Artificial intelligence for natural product drug discovery

Mullowney, Michael W. ; Duncan, Katherine R. ; Elsayed, Somayah S. ; Garg, Neha ; van der Hooft, Justin J.J. ; Martin, Nathaniel I. ; Meijer, David ; Terlouw, Barbara R. ; Biermann, Friederike ; Blin, Kai ; Durairaj, Janani ; Gorostiola González, Marina ; Helfrich, Eric J.N. ; Huber, Florian ; Leopold-Messer, Stefan ; Rajan, Kohulan ; de Rond, Tristan ; van Santen, Jeffrey A. ; Sorokina, Maria ; Balunas, Marcy J. ; Beniddir, Mehdi A. ; van Bergeijk, Doris A. ; Carroll, Laura M. ; Clark, Chase M. ; Clevert, Djork Arné ; Dejong, Chris A. ; Du, Chao ; Ferrinho, Scarlet ; Grisoni, Francesca ; Hofstetter, Albert ; Jespers, Willem ; Kalinina, Olga V. ; Kautsar, Satria A. ; Kim, Hyunwoo ; Leao, Tiago F. ; Masschelein, Joleen ; Rees, Evan R. ; Reher, Raphael ; Reker, Daniel ; Schwaller, Philippe ; Segler, Marwin ; Skinnider, Michael A. ; Walker, Allison S. ; Willighagen, Egon L. ; Zdrazil, Barbara ; Ziemert, Nadine ; Goss, Rebecca J.M. ; Guyomard, Pierre ; Volkamer, Andrea ; Gerwick, William H. ; Kim, Hyun Uk ; Müller, Rolf ; van Wezel, Gilles P. ; van Westen, Gerard J.P. ; Hirsch, Anna K.H. ; Linington, Roger G. ; Robinson, Serina L. ; Medema, Marnix H.
in: Nature Reviews Drug Discovery, vol: 22, pages: 895-916

Type: Review (Peer reviewed)

Status: Published | Year: 2023 | DOI: https://doi.org/10.1038/s41573-023-00774-7

Complete, circular genome sequence of a Bosea sp. isolate from soil

Alvarez-Arevalo, Maria ; Sterndorff, Eva Baggesgaard ; Faurdal, David ; Mourched, Anna Sophie ; Charusanti, Pep ; Jørgensen, Tue Sparholt ; Weber, Tilmann
in: Microbiology Resource Announcements, vol: 12, issue: 9, pages: 1-3

Type: Journal article (Peer reviewed)

Status: Published | Year: 2023 | DOI: https://doi.org/10.1128/MRA.00360-23