CHO In Silico Engineering of Glycosylation & Protein Quality

The CHO In Silico Engineering of Glycosylation and Protein Quality group has successfully developed genomic and computational tools for data analysis. It thus guides the approaches for CHO cell engineering by the other CFB groups in the CHO Program.

Our specific aims are:

  • To expand and refine genomic resources to improve efforts to edit CHO cells with increased productivity and increased DNA stability to protect protein quality.  
  • To establish a modelling platform for predictive engineering of glycosylation in CHO cells to facilitate biosimilar and bio-better development.
  • To develop a computational platform for simulating and analysis of protein synthesis and secretion in CHO cells to unravel cellular determinants of high productivity.

This group is headed by Nathan E. Lewis from UCSD.