Publications

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2020
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Accelerated genome engineering of Pseudomonas putida by I-SceI-mediated recombination and CRISPR-Cas9 counterselection

Wirth, Nicolas ; Kozaeva, Ekaterina ; Nikel, Pablo Ivan
in: Microbial Biotechnology, vol: 13, issue: 1, pages: 233-249

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1111/1751-7915.13396

 

Adaptive laboratory evolution of Escherichia coli under acid stress

Du, Bin ; Olson, Connor A. ; Sastry, Anand V ; Fang, Xin ; Phaneuf, Patrick V. ; Chen, Ke ; Wu, Muyao ; Szubin, Richard ; Xu, Sibei ; Gao, Ye ; Hefner, Ying ; Feist, Adam M ; Palsson, Bernhard O
in: Microbiology

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2020     |    DOI: https://doi.org/10.1099/mic.0.000867

 

Addressing environmental sustainability of biochemicals

Ögmundarson, Ólafur ; Herrgård, Markus J. ; Forster, Jochen ; Hauschild, Michael Zwicky ; Fantke, Peter
in: Nature Sustainability

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2020     |    DOI: https://doi.org/10.1038/s41893-019-0442-8

 

Awakening dormant glycosyltransferases in CHO cells with CRISPRa

Julie la Cour Karottki, Karen ; Hefzi, Hooman ; Xiong, Kai ; Shamie, Isaac ; Hansen, Anders Holmgaard ; Li, Songyuan ; Pedersen, Lasse Ebdrup ; Li, Shangzhong ; Lee, Jae Seong ; Min Lee, Gyun ; Kildegaard, Helene Faustrup ; Lewis, Nathan E.
in: Biotechnology and Bioengineering, vol: 117, issue: 2, pages: 593-598

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1002/bit.27199

 

A workflow for generating multi-strain genome-scale metabolic models of prokaryotes

Norsigian, Charles J. ; Fang, Xin ; Seif, Yara ; Monk, Jonathan M. ; Palsson, Bernhard O.
in: Nature Protocols, vol: 15, issue: 1, pages: 1-14

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1038/s41596-019-0254-3

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Biochemistry, genetics and biotechnology of glycerol utilization in Pseudomonas species

Poblete-Castro, Ignacio ; Wittmann, Christoph ; Nikel, Pablo Ivan
in: Microbial Biotechnology, vol: 13, issue: 1, pages: 32-53

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1111/1751-7915.13400

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Complete Genome Sequences of 13 Bacillus subtilis Soil Isolates for Studying Secondary Metabolite Diversity

Kiesewalter, Heiko T. ; Lozano-Andrade, Carlos N. ; Maróti, Gergely ; Snyder, Dan ; Jørgensen, Tue Sparholt ; Weber, Tilmann ; Kovács, Ákos T.
in: Microbiology Resource Announcements, vol: 9, issue: 2

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1128/mra.01406-19

 

Dual-function chromogenic screening-based CRISPR/Cas9 genome editing system for actinomycetes

Wang, Qiushui ; Xie, Feng ; Tong, Yaojun ; Habisch, Rebecca ; Yang, Bowen ; Zhang, Lixin ; Müller, Rolf ; Fu, Chengzhang
in: Applied Microbiology and Biotechnology, vol: 104, pages: 225-239

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1007/s00253-019-10223-4

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Engineering G protein-coupled receptor signalling in yeast for biotechnological and medical purposes

Lengger, Bettina ; Jensen, Michael Krogh
in: FEMS Yeast Research

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2020     |    DOI: https://doi.org/10.1093/femsyr/foz087

 

Engineering yeast phospholipid metabolism for de novo oleoylethanolamide production

Liu, Yi ; Liu, Quanli ; Krivoruchko, Anastasia ; Khoomrung, Sakda ; Nielsen, Jens
in: Nature Chemical Biology

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2020     |    DOI: https://doi.org/10.1038/s41589-019-0431-2

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Environmental hotspots of lactic acid production systems

Ögmundarson, Ólafur ; Sukumara, Sumesh ; Laurent, Alexis ; Fantke, Peter
in: GCB Bioenergy, vol: 12, issue: 1, pages: 19-38

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1111/gcbb.12652

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Evolution-guided engineering of small-molecule biosensors

Snoek, Tim ; Chaberski, Evan Kirk ; Ambri, Francesca ; Kol, Stefan ; Bjørn, Sara P ; Pang, Bo ; Barajas, Jesus F ; Welner, Ditte Hededam ; Jensen, Michael Krogh ; Keasling, Jay D.
in: Nucleic acids research, vol: 48, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1093/nar/gkz954

 

Genome Mining Approaches to Bacterial Natural Product Discovery

Ziemert, Nadine ; Weber, Tilmann ; Medema, Marnix H.
in: Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2020     |    DOI: https://doi.org/10.1016/B978-0-12-409547-2.14627-X

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Insights into the Mechanism of Phenylacetate Decarboxylase (PhdB), a Toluene-Producing Glycyl Radical Enzyme

Rodrigues, Andria V. ; Tantillo, Dean J. ; Mukhopadhyay, Aindrila ; Keasling, Jay ; Beller, Harry R.
in: ChemBioChem

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2020     |    DOI: https://doi.org/10.1002/cbic.201900560

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Leveraging host metabolism for bisdemethoxycurcumin production in Pseudomonas putida

Incha, Matthew R. ; Thompson, Mitchell G. ; Blake-Hedges, Jacquelyn M. ; Liu, Yuzhong ; Pearson, Allison N. ; Schmidt, Matthias ; Gin, Jennifer W. ; Petzold, Christopher J. ; Deutschbauer, Adam M. ; Keasling, Jay D.
in: Metabolic Engineering Communications, vol: 10

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1016/j.mec.2019.e00119

 

Lipid and carotenoid production from wheat straw hydrolysates by different oleaginous yeasts

Liu, Zhijia ; Feist, Adam ; Dragone, Giuliano ; Mussatto, Solange I.
in: Journal of Cleaner Production

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2020     |    DOI: https://doi.org/10.1016/j.jclepro.2019.119308

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MIBiG 2.0: a repository for biosynthetic gene clusters of known function

Kautsar, Satria A ; Blin, Kai ; Shaw, Simon ; Navarro-Muñoz, Jorge C ; Terlouw, Barbara R ; van der Hooft, Justin J J ; van Santen, Jeffrey A ; Tracanna, Vittorio ; Suarez Duran, Hernando G ; Pascal Andreu, Victòria ; Selem-Mojica, Nelly ; Alanjary, Mohammad ; Robinson, Serina L ; Lund, George ; Epstein, Samuel C ; Sisto, Ashley C ; Charkoudian, Louise K ; Collemare, Jérôme ; Linington, Roger G ; Weber, Tilmann ; Medema, Marnix H
in: Nucleic acids research, vol: 48, pages: D454–D458

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1093/nar/gkz882

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Optimizing cultivation of Cordyceps militaris for fast growth and cordycepin overproduction using rational design of synthetic media

Raethong, Nachon ; Wang, Hao ; Nielsen, Jens ; Vongsangnak, Wanwipa
in: Computational and Structural Biotechnology Journal, vol: 18, pages: 1-8

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1016/j.csbj.2019.11.003

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Physical decoupling of XylS/Pm regulatory elements and conditional proteolysis enable precise control of gene expression in Pseudomonas putida

Volke, Daniel Christoph ; Turlin, Justine ; Mol, Viviënne ; Nikel, Pablo Ivan
in: Microbial Biotechnology, vol: 13, issue: 1, pages: 222-232

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1111/1751-7915.13383

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Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast

Jakočiūnas, Tadas ; Klitgaard, Andreas K. ; Kontou, Eftychia Eva ; Nielsen, Julie Bang ; Thomsen, Emil ; Romero Suarez, David ; Blin, Kai ; Petzold, Christopher J. ; Gin, Jennifer W. ; Tong, Yaojun ; Gotfredsen, Charlotte Held ; Charusanti, Pep ; Frandsen, Rasmus J. N. ; Weber, Tilmann ; Lee, Sang Yup ; Jensen, Michael Krogh ; Keasling, Jay D.
in: Synthetic and Systems Biotechnology, vol: 5, issue: 1, pages: 11-18

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1016/j.synbio.2020.01.004

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Protocols for RecET-based markerless gene knockout and integration to express heterologous biosynthetic gene clusters in Pseudomonas putida

Choi, Kyeong Rok ; Lee, Sang Yup
in: Microbial Biotechnology, vol: 13, issue: 1, pages: 199-209

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1111/1751-7915.13374

 

Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories

Li, Meijie ; Hou, Feifei ; Wu, Tong ; Jiang, Xinglin ; Li, Fuli ; Liu, Haobao ; Xian, Mo ; Zhang, Haibo
in: Natural Product Reports

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2020     |    DOI: https://doi.org/10.1039/c9np00016j

 

The Mobilome: Metagenomic Analysis of Circular Plasmids, Viruses, and Other Extrachromosomal Elements

Browne, Patrick Denis ; Kot, Witold ; Jørgensen, Tue Sparholt ; Hansen, Lars Hestbjerg
part of: Horizontal Gene Transfer, pages: 253-264, 2020

Type: Book chapter

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1007/978-1-4939-9877-7_18

 

Yeast systems biology in understanding principles of physiology underlying complex human diseases

Yu, Rosemary ; Nielsen, Jens
in: Current Opinion in Biotechnology, vol: 63, pages: 63-69

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1016/j.copbio.2019.11.021

2019
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A high-throughput platform to select for regulators of crispr-cas associated activity

Vazquez-Uribe, Ruben ; Van Der Helm, Eric ; Sommer, Morten Otto Alexander ; Lee, Sang Woo
Patent no.: WO2019185750, Date: 2019-03-27

Type: Patent

Status: Published     |    Year: 2019

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Inhibitors of crispr-cas associated activity

Vazquez-Uribe, Ruben ; Van Der Helm, Eric ; Sommer, Morten Otto Alexander ; Misiakou, Maria-Anna ; Lee, Sang Woo
Patent no.: WO2019185751, Date: 2019-03-27

Type: Patent

Status: Published     |    Year: 2019

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Glycosylation of proteins

Voldborg, Bjørn ; Kol, Stefan ; Hansen, Anders ; Kildegaard, Helene
Patent no.: WO2019105770, Date: 2017-11-28

Type: Patent

Status: Published     |    Year: 2019

 

Synthetic Biology of Yeast

Liu, Zihe ; Zhang, Yueping ; Nielsen, Jens
in: Biochemistry, vol: 58, issue: 11, pages: 1511-1520

Type: Review (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1021/acs.biochem.8b01236

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Identification of genes involved in shea butter biosynthesis from Vitellaria paradoxa fruits through transcriptomics and functional heterologous expression

Wei, Yongjun ; Ji, Boyang ; Siewers, Verena ; Xu, Deyang ; Halkier, Barbara Ann ; Nielsen, Jens
in: Applied Microbiology and Biotechnology, vol: 103, issue: 9, pages: 3727-3736

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1007/s00253-019-09720-3

 

3.53 Synthetic Biology: An Overview

de Carvalho, Ângela ; Garcia Vanegas, Katherina ; Pereira, Filipa ; Theobald, Sebastian ; Takos, Adam
part of: Comprehensive Biotechnology 3rd Edition, pages: 659-670, 2019, Pergamon Press

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2019

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A carbohydrate-binding family 48 module enables feruloyl esterase action on polymeric arabinoxylan

Holck, Jesper ; Fredslund, Folmer ; Møller, Marie Sofie ; Brask, Jesper ; Krogh, Kristian B. R. M. ; Lange, Lene ; Welner, Ditte Hededam ; Svensson, Birte ; Meyer, Anne S. ; Wilkens, Casper
in: Journal of Biological Chemistry, vol: 294, issue: 46, pages: 17339-17353

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1074/jbc.RA119.009523

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Accelerated H-2 Evolution during Microbial Electrosynthesis with Sporomusa ovata

Tremblay, Pier-Luc ; Faraghiparapari, Neda ; Zhang, Tian
in: Catalysts, vol: 9, issue: 2

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.3390/catal9020166

 

A comprehensive metabolic map for production of bio-based chemicals

Lee, Sang Yup ; Kim, Hyun Uk ; Chae, Tong Un ; Cho, Jae Sung ; Kim, Je Woong ; Shin, Jae Ho ; Kim, Dong In ; Ko, Yoo Sung ; Jang, Woo Dae ; Jang, Yu Sin
in: Nature Catalysis, vol: 2, issue: 1, pages: 18-33

Type: Review (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41929-018-0212-4

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A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism

Lu, Hongzhong ; Li, Feiran ; Sánchez, Benjamín J ; Zhu, Zhengming ; Li, Gang ; Domenzain, Iván ; Marcišauskas, Simonas ; Anton, Petre Mihail ; Lappa, Dimitra ; Lieven, Christian ; Beber, Moritz Emanuel ; Sonnenschein, Nikolaus ; Kerkhoven, Eduard J ; Nielsen, Jens
in: Nature Communications, vol: 10, issue: 1, pages: 3586

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41467-019-11581-3

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A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules

Liang, Mindong ; Li, Zilong ; Wang, Weishan ; Liu, Jiakun ; Liu, Leshi ; Zhu, Guoliang ; Karthik, Loganathan ; Wang, Man ; Wang, Ke Feng ; Wang, Zhong ; Yu, Jing ; Shuai, Yuting ; Yu, Jiaming ; Zhang, Lu ; Yang, Zhiheng ; Li, Chuan ; Zhang, Qian ; Shi, Tong ; Zhou, Liming ; Xie, Feng ; Dai, Huanqin ; Liu, Xueting ; Zhang, Jingyu ; Liu, Guang ; Zhuo, Ying ; Zhang, Buchang ; Liu, Chenli ; Li, Shanshan ; Xia, Xuekui ; Tong, Yaojun ; Liu, Yanwen ; Alterovitz, Gil ; Tan, Gao Yi ; Zhang, Li Xin
in: Nature Communications, vol: 10, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41467-019-11648-1

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Adapting to the airways: Metabolic requirements of Pseudomonas aeruginosa during the infection of cystic fibrosis patients

La Rosa, Ruggero ; Johansen, Helle Krogh ; Molin, Søren
in: Metabolites, vol: 9, issue: 10

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.3390/metabo9100234

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Adaptive evolution reveals a tradeoff between growth rate and oxidative stress during naphthoquinone-based aerobic respiration

Anand, Amitesh ; Chen, Ke ; Yang, Laurence ; Sastry, Anand V. ; Olson, Connor A. ; Poudel, Saugat ; Seif, Yara ; Hefner, Ying ; Phaneuf, Patrick V. ; Xu, Sibei ; Szubin, Richard ; Feist, Adam ; Palsson, Bernhard
in: Proceedings of the National Academy of Sciences of the United States of America, vol: 116, issue: 50, pages: 25287-25292

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1073/pnas.1909987116

 

Adaptive laboratory evolution of tolerance to dicarboxylic acids in Saccharomyces cerevisiae

Pereira, Rui ; Wei, Yongjun ; Mohamed, Elsayed Tharwat Tolba ; Radi, Mohammad ; Malina, Carl ; Herrgård, Markus J. ; Feist, Adam M. ; Nielsen, Jens ; Chen, Yun
in: Metabolic Engineering, vol: 56, pages: 130-141

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.ymben.2019.09.008

 

A gender matching effect in learning with pedagogical agents in an immersive virtual reality science simulation

Makransky, Guido ; Wismer, Philip ; Mayer, Richard E.
in: Journal of Computer Assisted Learning, vol: 35, issue: 3, pages: 349-358

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1111/jcal.12335

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A gRNA-tRNA array for CRISPR-Cas9 based rapid multiplexed genome editing in Saccharomyces cerevisiae

Zhang, Yueping ; Wang, Juan ; Wang, Zibai ; Zhang, Yiming ; Shi, Shuobo ; Nielsen, Jens ; Liu, Zihe
in: Nature Communications, vol: 10

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41467-019-09005-3

 

A High-Throughput Mass Spectrometric Enzyme Activity Assay Enabling the Discovery of Cytochrome P450 Biocatalysts

de Rond, Tristan ; Gao, Jian ; Zargar, Amin ; de Raad, Markus ; Cunha, Jack ; Northen, Trent R. ; Keasling, Jay D.
in: ANGEWANDTE CHEMIE, vol: 58, issue: 30, pages: 10114-10119

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1002/anie.201901782

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Aledb 1.0: A database of mutations from adaptive laboratory evolution experimentation

Phaneuf, Patrick V. ; Gosting, Dennis ; Palsson, Bernhard O. ; Feist, Adam M.
in: Nucleic acids research, vol: 47, issue: D1, pages: D1164-D1171

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1093/nar/gky983

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A metabolic reconstruction of Lactobacillus reuteri JCM 1112 and analysis of its potential as a cell factory

Kristjansdottir, Thordis ; Bosma, Elleke Fenna ; Branco Dos Santos, Filipe ; Özdemir, Emre ; Herrgård, Markus J. ; França, Lucas ; Ferreira, Bruno ; Toftgaard Nielsen, Alex ; Gudmundsson, Steinn
in: Microbial Cell Factories, vol: 18, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1186/s12934-019-1229-3

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Analysis of Pseudomonas putida growth on non-trivial carbon sources using transcriptomics and genome-scale modeling

D'Arrigo, Isotta ; Cardoso, João G. R. ; Rennig, Maja ; Sonnenschein, Nikolaus ; Herrgård, Markus J. ; Long, Katherine S.
in: Environmental Microbiology Reports, vol: 11, issue: 2, pages: 87-97

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1111/1758-2229.12704

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Antibacterial effect of boron nitride flakes with controlled orientation in polymer composites

Pandit, Santosh ; Gaska, Karolina ; Mokkapati, V. R.S.S. ; Forsberg, Sven ; Svensson, Magnus ; Kádár, Roland ; Mijakovic, Ivan
in: RSC Advances, vol: 9, issue: 57, pages: 33454-33459

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1039/c9ra06773f

 

Antibiotic Lethality Is Impacted by Nutrient Availabilities: New Insights from Machine Learning

Nielsen, Jens
in: CELL, vol: 177, issue: 6, pages: 1373-1374

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.cell.2019.05.015

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Antibiotic Treatment Drives the Diversification of the Human Gut Resistome

Li, Jun ; Rettedal, Elizabeth A ; van der Helm, Eric ; Ellabaan, Mostafa M Hashim ; Panagiotou, Gianni ; Sommer, Morten Otto Alexander
in: Genomics, Proteomics and Bioinformatics, vol: 17, issue: 1, pages: 39-51

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.gpb.2018.12.003

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antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

Blin, Kai ; Shaw, Simon ; Steinke, Katharina ; Villebro, Rasmus ; Ziemert, Nadine ; Lee, Sang Yup ; Medema, Marnix H ; Weber, Tilmann
in: Nucleic acids research, vol: 87, issue: W2, pages: W81-W87

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1093/nar/gkz310

 

Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus

Schafhauser, Thomas ; Jahn, Linda ; Kirchner, Norbert ; Kulik, Andreas ; Flor, Liane ; Lang, Alexander ; Caradec, Thibault ; Fewer, David P ; Sivonen, Kaarina ; van Berkel, Willem J H ; Jacques, Philippe ; Weber, Tilmann ; Gross, Harald ; van Pée, Karl-Heinz ; Wohlleben, Wolfgang ; Ludwig-Müller, Jutta
in: Proceedings of the National Academy of Sciences of the United States of America, vol: 52, pages: 26909-26917

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1073/pnas.1910527116

 

Aqueous two-phase systems (ATPS) as a tool to overcome product inhibition in lignocellulosic conversions

Bussamra, Bianca Consorti ; Viswanathan, Vidhvath ; Freitas, Sindelia ; Mussatto, Solange I. ; da Costa, Aline Carvalho ; van der Wielen, Luuk ; Ottens, Marcel
in: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, vol: 257

Type: Conference article (Peer reviewed)

Status: Published     |    Year: 2019

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A rapid methods development workflow for high-throughput quantitative proteomic applications

Chen, Yan ; Vu, Jonathan ; Thompson, Mitchell G. ; Sharpless, William A. ; Chan, Leanne Jade G. ; Gin, Jennifer W. ; Keasling, Jay D. ; Adams, Paul D. ; Petzold, Christopher J.
in: PLOS ONE, vol: 14, issue: 2

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1371/journal.pone.0211582

 

Are we there yet? How and when specific biotechnologies will improve human health

O'Day, Elizabeth ; Hosta-Rigau, Leticia ; Oyarzún, Diego A. ; Okano, Hideyuki ; de Lorenzo, Víctor ; von Kameke, Conrad ; Alsafar, Habiba ; Cao, Cong ; Chen, Guo-Qiang ; Ji, Weizhi ; Roberts, Richard J. ; Ronaghi, Mostafa ; Yeung, Karen ; Zhang, Feng ; Lee, Sang Yup
in: Biotechnology Journal, vol: 14, issue: 1, pages: 11

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1002/biot.201800195

 

A robotic platform to screen aqueous two-phase systems for overcoming inhibition in enzymatic reactions

Bussamra, Bianca Consorti ; Gomes, Joana Castro ; Freitas, Sindelia ; Mussatto, Solange I. ; da Costa, Aline Carvalho ; van der Wielen, Luuk ; Ottens, Marcel
in: Bioresource Technology, vol: 280, pages: 37-50

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.biortech.2019.01.136

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A Systematic Investigation of the Malignant Functions and Diagnostic Potential of the Cancer Secretome

Robinson, Jonathan L. ; Feizi, Amir ; Uhlén, Mathias ; Nielsen, Jens
in: Cell Reports, vol: 26, issue: 10, pages: 2622-2635

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.celrep.2019.02.025

 

Automated "cells-To-Peptides" Sample Preparation Workflow for High-Throughput, Quantitative Proteomic Assays of Microbes

Chen, Yan ; Guenther, Joel M. ; Gin, Jennifer W. ; Chan, Leanne Jade G. ; Costello, Zak ; Ogorzalek, Tadeusz L. ; Tran, Huu M. ; Blake-Hedges, Jacquelyn M. ; Keasling, Jay D. ; Adams, Paul D. ; García Martín, Héctor ; Hillson, Nathan J. ; Petzold, Christopher J.
in: Journal of Proteome Research, vol: 18, issue: 10, pages: 3752-3761

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1021/acs.jproteome.9b00455

 

A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action

Yang, Jason H ; Wright, Sarah N ; Hamblin, Meagan ; McCloskey, Douglas ; Alcantar, Miguel A ; Schrübbers, Lars ; Lopatkin, Allison J ; Satish, Sangeeta ; Nili, Amir ; Palsson, Bernhard O ; Walker, Graham C ; Collins, James J
in: CELL, vol: 177, issue: 6, pages: 1649-1661.e9

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.cell.2019.04.016

 

BCAT1 and BCAT2 disruption in CHO cells has cell line-dependent effects

Pereira, Sara ; Ley, Daniel ; Schubert, Mikkel ; Grav, Lise Marie ; Kildegaard, Helene Faustrup ; Andersen, Mikael Rørdam
in: Journal of Biotechnology, vol: 306, pages: 24-31

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.jbiotec.2019.08.017

 

Big data in yeast systems biology

Yu, Rosemary ; Nielsen, Jens
in: FEMS Yeast Research, vol: 19, issue: 7

Type: Review (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1093/femsyr/foz070

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Bioaugmentation with Lactobacillus delbrueckii to enhance the production of lactic acid from municipal biopulp

Alvarado-Morales, Merlin ; Tsapekos, Panagiotis ; Bosma, Elleke Fenna ; Baladi, Samin ; Angelidaki, Irini
Presented at:
16th World Congress on Anaerobic Digestion

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2019

 

BiP Inducer X: An ER Stress Inhibitor for Enhancing Recombinant Antibody Production in CHO Cell Culture

Kwang Ha, Tae ; Hansen, Anders H ; Kildegaard, Helene Faustrup ; Min Lee, Gyun
in: Biotechnology Journal

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1002/biot.201900130

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BOFdat: Generating biomass objective functions for genome-scale metabolic models from experimental data

Lachance, Jean Christophe ; Lloyd, Colton J. ; Monk, Jonathan M. ; Yang, Laurence ; Sastry, Anand V. ; Seif, Yara ; Palsson, Bernhard O. ; Rodrigue, Sébastien ; Feist, Adam M. ; King, Zachary A. ; Jacques, Pierre Étienne
in: PLOS Computational Biology, vol: 15, issue: 4

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1371/journal.pcbi.1006971

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Breaking the state-of-the-art in the chemical industry with new-to-Nature products via synthetic microbiology

Martinelli, Laura ; Nikel, Pablo Ivan
in: Microbial Biotechnology, vol: 12, issue: 2, pages: 187-190

Type: Editorial (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1111/1751-7915.13372

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Building a global alliance of biofoundries

Hillson, Nathan ; Caddick, Mark ; Cai, Yizhi ; Carrasco, Jose A. ; Chang, Matthew Wook ; Curach, Natalie C. ; Bell, David J. ; Le Feuvre, Rosalind ; Friedman, Douglas C. ; Fu, Xiongfei ; Gold, Nicholas D. ; Herrgård, Markus J. ; Holowko, Maciej B. ; Johnson, James R. ; Johnson, Richard A. ; Keasling, Jay D. ; Kitney, Richard I. ; Kondo, Akihiko ; Liu, Chenli ; Martin, Vincent J.J. ; Menolascina, Filippo ; Ogino, Chiaki ; Patron, Nicola J. ; Pavan, Marilene ; Poh, Chueh Loo ; Pretorius, Isak S. ; Rosser, Susan J. ; Scrutton, Nigel S. ; Storch, Marko ; Tekotte, Hille ; Travnik, Evelyn ; Vickers, Claudia E. ; Yew, Wen Shan ; Yuan, Yingjin ; Zhao, Huimin ; Freemont, Paul S.
in: Nature Communications, vol: 10

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41467-019-10079-2

 

Carbohydrate active enzymes are affected by diet transition from milk to solid food in infant gut microbiota

Ye, Lingqun ; Das, Promi ; Li, Peishun ; Ji, Boyang ; Nielsen, Jens
in: FEMS Microbiology Ecology, vol: 95, issue: 11

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1093/femsec/fiz159

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Cell factory engineering for improved production of natural products

Nielsen, Jens
in: Natural Product Reports, vol: 36, issue: 9, pages: 1233-1236

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1039/c9np00005d

 

Cellular responses to reactive oxygen species are predicted from molecular mechanisms

Yang, Laurence ; Mih, Nathan ; Anand, Amitesh ; Park, Joon Ho ; Tan, Justin ; Yurkovich, James T. ; Monk, Jonathan M. ; Lloyd, Colton J. ; Sandberg, Troy E. ; Seo, Sang Woo ; Kim, Donghyuk ; Sastry, Anand V. ; Phaneuf, Patrick ; Gao, Ye ; Broddrick, Jared T. ; Chen, Ke ; Heckmann, David ; Szubin, Richard ; Hefner, Ying ; Feist, Adam M. ; Palsson, Bernhard O.
in: Proceedings of the National Academy of Sciences of the United States of America, vol: 116, issue: 28, pages: 14368-14373

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1073/pnas.1905039116

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Changing substrate specificity and iteration of amino acid chain elongation in glucosinolate biosynthesis through targeted mutagenesis of Arabidopsis methylthioalkylmalate synthase 1

Petersen, Annette ; Gram Hansen, Lea ; Mirza, Nadia ; Crocoll, Christoph ; Mirza, Osman ; Halkier, Barbara Ann
in: Bioscience Reports, vol: 39, issue: 7

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1042/BSR20190446

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Characterization of CA-MRSA TCH1516 exposed to nafcillin in bacteriological and physiological media

Poudel, Saugat ; Tsunemoto, Hannah ; Meehan, Michael ; Szubin, Richard ; Olson, Connor A. ; Lamsa, Anne ; Seif, Yara ; Dillon, Nicholas ; Vrbanac, Alison ; Sugie, Joseph ; Dahesh, Samira ; Monk, Jonathan M. ; Dorrestein, Pieter C. ; Pogliano, Joseph ; Knight, Rob ; Nizet, Victor ; Palsson, Bernhard O. ; Feist, Adam M.
in: Scientific Data, vol: 6, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41597-019-0051-4

 

Characterization of Hypermutator Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis in Australia

Rees, Vanessa Emily ; Deveson Lucas, Deanna S. ; López-Causapé, Carla ; Huang, Yuling ; Kotsimbos, Tom ; Bulitta, Jürgen B. ; Rees, Murray C. ; Barugahare, Adele ; Peleg, Anton Y. ; Nation, Roger L. ; Oliver, Antonio ; Boyce, John D. ; Landersdorfer, Cornelia B.
in: Antimicrobial Agents and Chemotherapy, vol: 63, issue: 4

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1128/AAC.02538-1

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Chasing bacterial chassis for metabolic engineering: a perspective review from classical to non-traditional microorganisms

Calero, Patricia ; Nikel, Pablo I.
in: Microbial Biotechnology, vol: 12, issue: 1, pages: 98-124

Type: Review (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1111/1751-7915.13292

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ChIP-exo analysis highlights Fkh1 and Fkh2 transcription factors as hubs that integrate multi-scale networks in budding yeast

Mondeel, Thierry D.G.A. ; Holland, Petter ; Nielsen, Jens ; Barberis, Matteo
in: Nucleic acids research, vol: 47, issue: 15, pages: 7825-7841

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1093/nar/gkz603

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Chromophore pre-maturation for improved speed and sensitivity of split-GFP monitoring of protein secretion

Lundqvist, Magnus ; Thalén, Niklas ; Volk, Anna Luisa ; Hansen, Henning Gram ; von Otter, Eric ; Nygren, Per-Åke ; Uhlén, Mathias ; Rockberg, Johan
in: Scientific Reports, vol: 9, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41598-018-36559-x

 

Classification and enzyme kinetics of formate dehydrogenases for biomanufacturing via CO2 utilization

Nielsen, Christian Førgaard ; Lange, Lene ; Meyer, Anne S.
in: Biotechnology Advances, vol: 37, issue: 7

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.biotechadv.2019.06.007

 

Cocktails of human monoclonal IgG antibodies capable of neutralizing dendrotoxin-mediated neurotoxicity of black mamba venom in vivo

Laustsen, Andreas H. ; Karatt-Vellatt, Aneesh ; Masters, Edward W. ; Arias, Ana Silvia ; Pus, Urska ; Knudsen, Cecilie ; Oscoz, Saioa ; Slavny, Peter ; Griffiths, Daniel T. ; Luther, Alice M. ; Leah, Rachael A. ; Lindholm, Majken ; Lomonte, Bruno ; Mar a Guti rrez, Jos ; McCafferty, John
in: Toxicon, vol: 159, issue: Supp. 1, pages: S5-S6
Presented at:
19th EU-IST Congress

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.toxicon.2018.11.331

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Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase

Rosenkilde, Carola Elisa Heesemann ; Munck, Christian ; Porse, Andreas ; Linkevicius, Marius ; Andersson, Dan I. ; Sommer, Morten Otto Alexander
in: Nature Communications, vol: 10

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41467-019-08529-y

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Combating viral contaminants in CHO cells by engineering innate immunity

Chiang, Austin W.T. ; Li, Shangzhong ; Kellman, Benjamin P. ; Chattopadhyay, Gouri ; Zhang, Yaqin ; Kuo, Chih Chung ; Gutierrez, Jahir M. ; Ghazi, Faezeh ; Schmeisser, Hana ; Ménard, Patrice ; Petersen Bjørn, Sara ; Voldborg, Bjørn Gunnar ; Rosenberg, Amy S. ; Puig, Montserrat ; Lewis, Nathan E.
in: Scientific Reports, vol: 9, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41598-019-45126-x

 

Combined Rapid Injection NMR and Simulation Approach to Probe Redox-Dependent Pathway Control in Living Cells

Jensen, Pernille Rose ; Matos, Marta ; Sonnenschein, Nikolaus ; Meier, Sebastian
in: Analytical Chemistry, vol: 91, issue: 8, pages: 5395-5402

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1021/acs.analchem.9b00660

 

Combining Pro-peptide Engineering and Multisite Saturation Mutagenesis to Improve the Catalytic Potential of Keratinase

Su, Chang ; Gong, Jin Song ; Sun, Yu Xin ; Qin, Jiufu ; Zhai, Shen ; Li, Heng ; Li, Hui ; Lu, Zhen Ming ; Xu, Zheng Hong ; Shi, Jin Song
in: A C S Synthetic Biology, vol: 8, issue: 2, pages: 425-433

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1021/acssynbio.8b00442

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Comparative Transcriptome Analysis Shows Conserved Metabolic Regulation during Production of Secondary Metabolites in Filamentous Fungi

Nielsen, Jens ; Prigent, Sylvain ; Grijseels, Sietske ; Workman, Mhairi ; Ji, Boyang
in: mSystems, vol: 4, issue: 2

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1128/mSystems.00012-19

 

Complete biosynthesis of cannabinoids and their unnatural analogues in yeast

Luo, Xiaozhou ; Reiter, Michael A. ; d’Espaux, Leo ; Wong, Jeff ; Denby, Charles M. ; Lechner, Anna ; Zhang, Yunfeng ; Grzybowski, Adrian T. ; Harth, Simon ; Lin, Weiyin ; Lee, Hyunsu ; Yu, Changhua ; Shin, John ; Deng, Kai ; Benites, Veronica T. ; Wang, George ; Baidoo, Edward E.K. ; Chen, Yan ; Dev, Ishaan ; Petzold, Christopher J. ; Keasling, Jay D.
in: Nature, vol: 567, issue: 7746, pages: 123-126

Type: Letter (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41586-019-0978-9

  PDF

Complex I is bypassed during high intensity exercise

Nilsson, Avlant ; Björnson, Elias ; Flockhart, Mikael ; Larsen, Filip J. ; Nielsen, Jens
in: Nature Communications, vol: 10, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41467-019-12934-8

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Computational methods for microbial cell factory engineering aided by evolution

Jensen, Kristian

Type: Ph.D. thesis

Status: Published     |    Year: 2019

 

Concomitant consumption of glucose and lactate: A novel batch production process for CHO cells

Martínez-Monge, I. ; Comas, P. ; Triquell, J. ; Casablancas, A. ; Lecina, M. ; Paredes, C.J. ; Cairó, J.J.
in: Biochemical Engineering Journal, vol: 151

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.bej.2019.107358

 

Construction of mini-chemostats for high-throughput strain characterization

Bergenholm, David ; Liu, Guodong ; Hansson, David ; Nielsen, Jens
in: Biotechnology and Bioengineering, vol: 116, issue: 5, pages: 1029-1038

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1002/bit.26931

 

Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0

Heirendt, Laurent ; Arreckx, Sylvain ; Pfau, Thomas ; Mendoza, Sebastian N. ; Richelle, Anne ; Heinken, Almut ; Haraldsdottir, Hulda S. ; Wachowiak, Jacek ; Keating, Sarah M. ; Vlasov, Vanja ; Magnusdottir, Stefania ; Ng, Chiam Yu ; Preciat, German ; Zagare, Alise ; Chan, Siu Hung Joshua ; Aurich, Maike K. ; Clancy, Catherine M. ; Modamio, Jennifer ; Sauls, John T. ; Noronha, Alberto ; Bordbar, Aarash ; Cousins, Benjamin ; El Assal, Diana C. ; Valcarcel, Luis V. ; Apaolaza, Inigo ; Ghaderi, Susan ; Ahookhosh, Masoud ; Ben Guebila, Marouen ; Kostromins, Andrejs ; Sompairac, Nicolas ; Le, Hoai M. ; Ma, Ding ; Sun, Yuekai ; Wang, Lin ; Yurkovich, James T. ; Oliveira, Miguel A. P. ; Vuong, Phan T. ; El Assal, Lemmer P. ; Kuperstein, Inna ; Zinovyev, Andrei ; Hinton, H. Scott ; Bryant, William A. ; Aragon Artacho, Francisco J. ; Planes, Francisco J. ; Stalidzans, Egils ; Maass, Alejandro ; Vempala, Santosh ; Hucka, Michael ; Saunders, Michael A. ; Maranas, Costas D. ; Lewis, Nathan E. ; Sauter, Thomas ; Palsson, Bernhard O. ; Thiele, Ines ; Fleming, Ronan M. T.
in: Nature Protocols, vol: 14, issue: 3, pages: 639-702

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41596-018-0098-2

 

CRISPR/Cas9 as a Genome Editing Tool for Targeted Gene Integration in CHO Cells

Sergeeva, Daria ; Manuel Camacho Zaragoza, Jose ; Lee, Jae Seong ; Kildegaard, Helene Faustrup
part of: CRISPR Gene Editing, pages: 213-232, 2019

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1007/978-1-4939-9170-9_13

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CRISPR/Cas9-RNAi system for combinatorial metabolic engineering of Saccharomyces cerevisiae

Kildegaard, Kanchana Rueksomtawin ; Ribeiro Ramos Tramontin, Larissa ; Chekina, Ksenia ; Li, Mingji ; Goedecke, Tobias Justus ; Kristensen, Mette ; Borodina, Irina
in: Yeast, vol: 36, issue: 5, pages: 237-247

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1002/yea.3390

 

CRISPR/Cas-based genome engineering in natural product discovery

Tong, Yaojun ; Weber, Tilmann ; Lee, Sang Yup
in: Natural Product Reports, vol: 36, issue: 9, pages: 1225-1372

Type: Review (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1039/C8NP00089A

 

CRISPR Toolbox for Mammalian Cell Engineering

Sergeeva, Daria ; Julie la Cour Karottki, Karen ; Lee, Jae Seong ; Kildegaard, Helene Faustrup
part of: Cell Culture Engineering: Recombinant Protein Production, 2019

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2019

  PDF

Depiction of secondary metabolites and antifungal activity of Bacillus velezensis DTU001.

Devi, Sagarika ; Kiesewalter, Heiko T. ; Kovács, Renátó ; Frisvad, Jens Christian ; Weber, Tilmann ; Larsen, Thomas Ostenfeld ; Kovács, Ákos T. ; Ding, Ling
in: Synthetic and Systems Biotechnology, vol: 4, issue: 3, pages: 142-149

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.synbio.2019.08.002

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Development, Validation and Comprehensive Sensitivity Analysis of a Fermentation Model Expediting the Process Design of a Biorefinery

Vollmer, Nikolaus I. ; Gernaey, Krist V. ; Mussatto, Solange I. ; Sin, Gürkan
Presented at:
The 5th European Congress of Applied Biotechnology (ECAB5)

Type: Conference abstract for conference (Peer reviewed)

Status: Published     |    Year: 2019

 

Discovery and Characterization of Cas9 Inhibitors Disseminated across Seven Bacterial Phyla

Vazquez-Uribe, Ruben ; van der Helm, Eric ; Misiakou, Maria-Anna ; Lee, Sang-Woo ; Kol, Stefan ; Sommer, Morten Otto Alexander
in: Cell Host & Microbe, vol: 25, issue: 2, pages: 233-241

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.chom.2019.01.003

 

Distinct functional roles for hopanoid composition in the chemical tolerance of Zymomonas mobilis

Brenac, Lea ; Baidoo, Edward E. K. ; Keasling, Jay D. ; Budin, Itay
in: Molecular Microbiology, vol: 112, issue: 5, pages: 1564-1575

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1111/mmi.14380