Lasse Ebdrup Pedersen

Lasse Ebdrup Pedersen

Senior Researcher and Co-PI

DTU BIOSUSTAIN
Novo Nordisk Foundation Center for Biosustainability

CFB-S-CHO Cell Line Engineering And Design

Technical University of Denmark

Kemitorvet

Building 220, room 506F

2800 Kgs. Lyngby

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2020
 

Awakening dormant glycosyltransferases in CHO cells with CRISPRa

Julie la Cour Karottki, Karen ; Hefzi, Hooman ; Xiong, Kai ; Shamie, Isaac ; Hansen, Anders Holmgaard ; Li, Songyuan ; Pedersen, Lasse Ebdrup ; Li, Shangzhong ; Lee, Jae Seong ; Min Lee, Gyun ; Kildegaard, Helene Faustrup ; Lewis, Nathan E.
in: Biotechnology and Bioengineering, vol: 117, issue: 2, pages: 593-598

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2020     |    DOI: https://doi.org/10.1002/bit.27199

2019
  PDF

Genome-wide systematic identification of methyltransferase recognition and modification patterns

Jensen, Torbjørn Ølshøj ; Tellgren-Roth, Christian ; Redl, Stephanie Maria Anna ; Maury, Jérôme ; Baallal Jacobsen, Simo Abdessamad ; Pedersen, Lasse Ebdrup ; Nielsen, Alex Toftgaard
in: Nature Communications, vol: 10, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1038/s41467-019-11179-9

 

Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion

Ley, Daniel ; Pereira, Sara ; Pedersen, Lasse Ebdrup ; Arnsdorf, Johnny ; Hefzi, Hooman ; Davy, Anne Mathilde ; Kwang Ha, Tae ; Wulff, Tune ; Kildegaard, Helene Faustrup ; Andersen, Mikael Rørdam
in: Metabolic Engineering, vol: 56, pages: 120-129

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2019     |    DOI: https://doi.org/10.1016/j.ymben.2019.09.005

2018
  PDF

CasPER, a method for directed evolution in genomic contexts using mutagenesis and CRISPR/Cas9

Jakočiūnas, Tadas ; Pedersen, Lasse E. ; Lis, Alicia V. ; Jensen, Michael K. ; Keasling, Jay D.
in: Metabolic Engineering, vol: 48, pages: 288-296

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: https://doi.org/10.1016/j.ymben.2018.07.001

2017
  PDF

Engineered mammalian cells for production of recombinant proteins

Voldborg, Bjørn Gunnar ; Pedersen, Lasse Ebdrup
Patent no.: WO2017186671, Date: 2017-11-02

Type: Patent

Status: Published     |    Year: 2017

  PDF

Developing a CRISPR/Cas9 screening platform for Chinese hamster ovary cells

Karottki, K. J. L. C. ; Li, S. ; Pedersen, L. E. ; Hefzi, H. ; Spahn, P. ; Thomas, A. ; Lee, Jae Seong ; Lee, G. M. ; Lewis, N. E. ; Kildegaard, Helene Faustrup
in: FEBS Journal, vol: 284, issue: Suppl. 1, pages: 172-172
Presented at:
42nd FEBS congress

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017

  PDF

Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data

Lund, Anne Mathilde ; Kaas, Christian Schrøder ; Brandl, Julian ; Pedersen, Lasse Ebdrup ; Kildegaard, Helene Faustrup ; Kristensen, Claus ; Andersen, Mikael Rørdam
in: B M C Systems Biology, vol: 11, issue: 1

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1186/s12918-017-0414-4

  PDF

Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion

Beuchert Kallehauge, Thomas ; Li, Shangzhong ; Pedersen, Lasse Ebdrup ; Kwang Ha, Tae ; Ley, Daniel ; Andersen, Mikael Rørdam ; Kildegaard, Helene Faustrup ; Min Lee, Gyun ; Lewis, Nathan E.
in: Scientific Reports, vol: 7

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: https://doi.org/10.1038/srep40388