Read the interesting article published in Nature Biotechnology 33, 2015, by Sang Yup Lee and Hyun Uk Kim
Official KAIST press release
Industrial strain development requires system-wide engineeringand optimization of cellular metabolism while considering
industrially relevant fermentation and recovery processes. It
can be conceptualized as several strategies, which may be
implemented in an iterative fashion and in different orders. The
key challenges have been the time-, cost- and labor-intensive
processes of strain development owing to the difficulties in
understanding complex interactions among the metabolic,
gene regulatory and signaling networks at the cell level, which
are collectively represented as overall system performance
under industrial fermentation conditions.
Read the article here