Research Assistant in Yeast Synthetic Biology

Thursday 07 Oct 21

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We are seeking a talented and driven Research Assistant to work on protein engineering using high throughput screens in yeast. The candidate will join the Cell Architecture Group (PI Ryan T. Gill) at the Novo Nordisk Foundation Center for Biosustainability (CFB) in Denmark. The Cell Architecture Group is developing cellular engineering technologies based on high-throughput and multiplexed genome editing (CRISPR) for a wide range of downstream applications from industrial biotech to cell therapies. We operate under a design-build-test-learn philosophy and have a strong focus on commercialization of technology developed in the group. The CFB is part of the Technical University of Denmark and provides a world-class research environment with state-of-the-art facilities and advanced technologies with special emphasis on cell factory engineering and systems biology technologies.

Responsibilities and qualifications
The candidate will focus on designing and implementing CRISPR-based libraries for protein engineering in yeast. This work leverages on previous technologies developed in our laboratory (https://doi.org/10.1038/nbt.3718, https://doi.org/10.1021/acssynbio.0c00159 https://doi.org/10.1016/j.ymben.2018.07.007). The candidate will be expected to drive and assist the research project forward by taking an active role in defining project goals, planning experiments, and analyzing data.

Specific tasks include:

  • Design and implement genetic circuits in yeast
  • Design and implementation of CRISPR libraries
  • Screening of libraries using FACS
  • Libraries sequencing using automation workflows and NGS technologies
  • Design, implement and execute critical experiments associated with a research plan
  • Document experimental design and results in electronic lab notebooks
  • Analyze and organize data to draw meaningful conclusions

As a formal qualification, you must have a master’s degree in Biotechnology, Bioengineering, Molecular Biology or similar

Furthermore you must

  • Have experience with molecular biology/synthetic biology
  • Have experience with NGS library preparation and data analysis is a plus
  • Have excellence in independent problem solving
  • Enjoy sharing knowledge and experience with others
  • The ability to lead multiple projects and support collaborations

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The initial period of employment is 1 year.

The place of employment is the DTU main campus in Kgs. Lyngby, Denmark.

You can read more about career paths at DTU here.

Further information
Further information may be obtained from David Romero-Suarez, Postdoctoral Researcher (darosu@biosustain.dtu.dk) or Marina Mohr, Scientific Coordinator (marpan@biosustain.dtu.dk)

You can read more about Cell Architecture at www.biosustain.dtu.dk/research/research-groups/cell-architecture-ryan-gill

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.

Application procedure
Please submit your online application no later than 5 November 2021 (Danish time).

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • Application (cover letter)
  • CV
  • MSc Diploma
  • List of publications

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

The Cell Architecture section works with developing technologies within genome engineering. The technologies span the entire iterative biotechnological cycle consisting of the steps: design, build, test and learn. The group aims at developing genome engineering technologies that address society's growing need for engineered cells, which spans a broad range of application areas including human health, sustainability, novel materials, the microbiome and the environment among others. The vision is to develop and disseminate such technologies in manners that result in rapid adoption and generate broad and significant impact.

The Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain)
Recent progress in our ability to read and write genomic code, combined with advances in automation, analytics and data science, has fundamentally changed the scope and ambition of harnessing the potential of biological systems. Big data approaches and analysis of biological systems are key research instruments at the Center. DTU Biosustain utilizes these advances for microbial cell factory design to foster sustainable lifestyles in relation to three application areas: Sustainable Chemicals, Natural Products, and Microbial Foods.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,900 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.