Postdoc in Streptomyces Strain Design

Tuesday 13 Oct 20

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Are you a highly motivated postdoctoral researcher with an interest in CRISPR applications in microorganisms, and experience in molecular biology with actinomycetes, and would like to join our highly international research center, The Novo Nordisk Foundation for Biosustainability (DTU Biosustain), Technical University of Denmark? 

Then we may have an interesting opportunity: We are looking for a colleague in the newly established Strain Design Unit, headed by DTU Biosustain CEO Prof. Bernhard Palsson. This central unit is building cell factories for the various application areas of the institute. 

In the “Streptomyces Natural Products program” our natural product application area, coordinated by Prof. Tilmann Weber, we are using large-scale omics-data-driven methods to identify and characterize new bioactive compounds, understand their biosynthesis and regulation and use this knowledge to design and build cell factories for their production. 

Responsibilities and tasks 
You will be responsible for developing and implementing high-throughput methods for building Streptomyces strains within the Strain Design Unit. This work will be closely interacting with DTU Biosustain’s Genome Analytics unit, the DTU Biosustain Biofoundry and the Streptomyces-centered research group on Genome Mining/Engineering of cell factories to produce novel bioactive compounds. 

Specific tasks include:

  • Implementing new CRISPR-based methods to efficiently engineer streptomycetes.
  • Use these methods on model organisms like S. coelicolor, but also on poorly characterized actinomycetes producing novel compounds to implement targeted edits, such as knock-in/knock-out of secondary metabolite biosynthetic genes, regulators, genes involved in precursor supply.
  • Develop and implement high-throughput protein expression strategies for transcription factors for ChIP-exo applications.
  • Participate in campaigns to generate high quality transcriptomics data of streptomycetes.
  • You will author publications in high impact international peer reviewed journals

You hold a PhD degree (or equivalent) in a relevant area, such as microbiology, biotechnology, chemical engineering. 

Furthermore, it is highly advantageous if you have documented experience in working with streptomycetes or related actinomycetes or have previous experience with CRISPR technologies, natural product biosynthesis, and metabolic engineering of natural product biosynthesis pathways. 

As a person, 

  • you enjoy working in a highly internationally and interdisciplinary team of scientists and engineers and thrive on collaboration and teamwork
  • you are striving for excellence and have high ambitions on your work and yourself.
  • you are focused on the process as well as the outcome

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. 

Salary and terms of employment 
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.

orkplace is DTU’s main campus in Kgs. Lyngby, Denmark. 

You can read more about career paths at DTU here.  

Further information 
Further information may be obtained from Prof. Bernhard Palsson, email:, or Prof. Tilmann Weber, email:

You can read more about DTU Biosustain at

Application procedure
Please submit your online application no later than 10 November 2020 (local time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • Application (cover letter)
  • CV
  • Diploma (MSc/PhD)
  • List of publications

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. 

The Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain)
Recent progress in our ability to read and write genomic code, combined with advances in automation, analytics and data science, has fundamentally changed the scope and ambition of harnessing the potential of biological systems. Big data approaches and analysis of biological systems are key research instruments at the Center. DTU Biosustain utilizes these advances for microbial cell factory design to foster sustainable lifestyles in relation to three application areas: Sustainable Chemicals, Natural Products, and Microbial Foods. 

Technology for people 
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,000 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.