Cells optimised to produce substance that holds potential to improve ‘healthy ageing’

A new scientific study published in Nature Catalysis shows that baker's yeast can be designed and optimised to produce polyamines and polyamine analogues for tackling grand challenges in both the health and agricultural sector.

Octarine receives economical support to develop innovative cannabinoid therapies

Octarine, a spinout company from The Novo Nordisk Foundation Center for Biosustainability at DTU and University of Copenhagen, has now raised over 3 million USD.

Enduro Genetics on a positive curve to long-living fermentation

Warm winds are blowing over Enduro Genetics ApS. During the last year, the spinout from DTU Biosustain has raised 470,000 EUR in a pre-seed grant from the incubator BioInnovation Institute, and won an Innovation Fund Denmark grant and a prestigious project with the US Agile BioFoundry.

Bio-map charts production routes for industrial chemicals

Researchers now present a very detailed map on metabolic engineering routes for the production of a wide range of sustainable chemicals. This map will ease the construction of engineered microorganisms that can produce bio-chemicals. The research is published in Nature Catalysis.

Creating flavours and fragrances from “shiki” cell factories

A big new EU project called SHIKIFACTORY100 aims at producing more than 100 high value compounds and chemicals such as flavours and fragrances biologically. This will be done using genetically optimized cells, designed to produce the desired compounds through the cellular pathway called ‘shikimate’.

Tampering with cellular fats holds great promise

Researchers have found a way to engineer the lipid composition of cell membranes. The method described in Science makes it easier to investigate how cells are regulated by their membrane composition. This could lead to optimized cell factories and better understanding of the role of lipids in metabolic diseases, such as type 2 diabetes...

Professor Markus Herrgard on High Tech Summit: I hope that industry and academia can inspire each other

Industry and academia are presenting new technologies, ideas and future perspectives at this year’s High Tech Summit at DTU. Markus Herrgard look forward - to inspire and be inspired - by how others use data for bio-based production.

Analysing data accelerates the development of cell factories

They rarely steal the show and the big headlines, but the Analytics Unit at the Novo Nordisk Foundation Center for Biosustainability, DTU, is playing a crucial part in the Center’s scientific success stories.   Biosustain Magazine has met Head of the Analytical Core Facility and Senior Researcher, Hanne Bjerre Christensen, to a chat...

In need of female applicants? Let women do the job

Three keys to how scientists can succeed as entrepreneurs

Commercialising scientific research requires a heavy focus on patenting, risk taking and people with an entrepreneurial mindset.

Postdoc, Pseudomonas and Postcards

H.C. Ørsted fellow Lorena Fernandez-Cabezon will contribute to CfB's mission of developing novel and robust bacterial cell factories for the sustainable production of chemicals.

Unleash the potential of data

By developing integrated software platforms the time and cost of making cell factories should be reduced.

Enzyme engineering contribute to production of new-to-nature glycosides

A new research group will focus on developing enzyme biocatalysts for the industrial production of natural products used as aromas, fragrances, dyes and pharmaceuticals.

Growth decoupling make bacteria better at producing chemicals

A set of molecular switches enable researchers to push bacteria to produce higher amounts of desired chemicals and proteins. The idea is to limit cell growth while still maintaining the cells’ ability to produce chemicals.

CRISPR technologies have changed the ball game

We are in the middle of a CHO revolution where gene editing can offer a significant change in biopharmaceutical manufacturing.

The fight to make pheromones an affordable alternative to insecticides

Scientists at the Novo Nordisk Foundation Center for Biosustainability, DTU, will replace conventional insecticides with pheromones to protect plants from pests.

Evolution plays many tricks against large-scale bioproduction

Ultra-deep DNA sequencing of thousands of cells uncovers many competing mechanisms of evolution as a threat to efficient scale-up of biobased chemicals production. Evolution plays an underestimated role in bioprocesses and limits yields much more than previously anticipated.  

Pausing evolution makes bioproduction of chemicals affordable and efficient

Circumventing evolution in cell factories can pave the way for commercializing new biobased chemicals to large-scale.

How can research solve some of the world's major problems?

The Novo Nordisk Foundation Center for Biosustainability will host the first “Wine and Science” (Vin & Videnskab) event of the year in collaboration with the National History Museum of Denmark and the University of Copenhagen.