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Profile
Keywords
Biofilms, chronic infections, functional genomics, evolution, antibiotic resistance, bacterial physiology
The major research interest of the past 10 years has been
microbial biofilms in relation to cell-cell interactions and
developmental processes. The knowledge obtained in the course of
this work is now being further developed in connection with
detailed studies of microbial adaptation and evolution in cases
of chronic infections. These current research activities are
based on the assumption that fundamental studies of bacteria
physiology and ecology are essential if we wish to understand and
eventually interfere with such microbial infections. The
investigations employ several methods providing global
information about the cells’ genomes and functional genomics. In
particular, specific clones of bacteria infecting airways of
cystic fibrosis patients are studied. In connection with these
studies evolution of antibiotic resistance is an important topic
where the current focus point is resistance mechanisms involved
in tolerance to anti-microbial peptides. Development of various
types of laboratory model systems for simulation of human
infections in vitro has been added to the research
program.
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