Publications

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2018
 

Modeling the multi-scale mechanisms of macromolecular resource allocation

Yang, Laurence ; Yurkovich, James T ; King, Zachary A ; Palsson, Bernhard
in journal: Current Opinion in Microbiology (ISSN: 1369-5274) (DOI: http://dx.doi.org/10.1016/j.mib.2018.01.002), vol: 45, pages: 8-15, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1016/j.mib.2018.01.002

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Biochemical mechanisms determine the functional compatibility of heterologous genes

Porse, Andreas ; Schou, Thea S. ; Munck, Christian ; Ellabaan, Mostafa M Hashim ; Sommer, Morten Otto Alexander
in journal: Nature Communications (ISSN: 2041-1723) (DOI: http://dx.doi.org/10.1038/s41467-018-02944-3), vol: 9, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1038/s41467-018-02944-3

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Hijacking CRISPR-Cas for high-throughput bacterial metabolic engineering: advances and prospects

Mougiakos, Ioannis ; Bosma, Elleke Fenna ; Ganguly , Joyshree ; van der Oost, John ; van Kranenburg, Richard
in journal: Current Opinion in Biotechnology (ISSN: 0958-1669) (DOI: http://dx.doi.org/10.1016/j.copbio.2018.01.002), vol: 50, pages: 146-157, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1016/j.copbio.2018.01.002

 

Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

Pereira, Sara ; Kildegaard, Helene Faustrup ; Andersen, Mikael Rørdam
in journal: Biotechnology Journal (Online) (ISSN: 1860-7314) (DOI: http://dx.doi.org/10.1002/biot.201700499), 2018

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2018     |    DOI: http://dx.doi.org/10.1002/biot.201700499

 

Towards Improved Biophysical Calculations to Identify Disease-Causing Mutations

Lindorff-Larsen, Kresten ; Stein, Amelie ; Teilum, Kaare ; Nielsen, Alex Toftgaard ; Hartmann-Petersen, Rasmus
in journal: Biophysical Journal (ISSN: 0006-3495) (DOI: http://dx.doi.org/10.1016/j.bpj.2017.11.1115), vol: 114, issue: 3, Suppl 1, pages: 199a, 2018

Type: Conference abstract in journal (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1016/j.bpj.2017.11.1115

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ClusterCAD: a computational platform for type I modular polyketide synthase design

Eng, Clara H. ; Backman, Tyler W. H. ; Bailey, Constance B. ; Magnan, Christophe ; Martin, Hector Garcia ; Katz, Leonard ; Baldi, Pierre ; Keasling, Jay
in journal: Nucleic Acids Research (ISSN: 0305-1048) (DOI: http://dx.doi.org/10.1093/nar/gkx893), vol: 46, issue: D1, pages: D509-D515, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1093/nar/gkx893

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Constraining genome-scale models to represent the bow tie structure of metabolism for 13C metabolic flux analysis

Backman, Tyler W.H. ; Ando, David ; Singh, Jahnavi ; Keasling, Jay ; Martín, Héctor García
in journal: Metabolites (ISSN: 2218-1989) (DOI: http://dx.doi.org/10.3390/metabo8010003), vol: 8, issue: 1, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.3390/metabo8010003

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Isolation and characterization of novel mutations in the pSC101 origin that increase copy number

Thompson, Mitchell G. ; Sedaghatian, Nima ; Barajas, Jesus F. ; Wehrs, Maren ; Bailey, Constance B. ; Kaplan, Nurgul ; Hillson, Nathan J. ; Mukhopadhyay, Aindrila ; Keasling, Jay
in journal: Scientific Reports (ISSN: 2045-2322) (DOI: http://dx.doi.org/10.1038/s41598-018-20016-w), vol: 8, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1038/s41598-018-20016-w

 

Universal Alternative Splicing of Noncoding Exons

Deveson, Ira W ; Brunck, Marion E ; Blackburn, James ; Tseng, Elizabeth ; Hon, Ting ; Clark, Tyson A ; Clark, Michael B ; Crawford, Joanna ; Dinger, Marcel E ; Nielsen, Lars Keld ; Mattick, John S ; Mercer, Tim R
in journal: Cell Systems (ISSN: 2405-4712) (DOI: http://dx.doi.org/10.1016/j.cels.2017.12.005), 2018

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2018     |    DOI: http://dx.doi.org/10.1016/j.cels.2017.12.005

 

"It's a gut feeling" - Escherichia coli biofilm formation in the gastrointestinal tract environment

Rossi, Elio ; Cimdins, Annika ; Luthje, Petra ; Brauner, Annelie ; Sjoling, Asa ; Landini, Paolo ; Romling, Ute
in journal: Critical Reviews in Microbiology (ISSN: 1040-841X) (DOI: http://dx.doi.org/10.1080/1040841X.2017.1303660), vol: 44, issue: 1, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1080/1040841X.2017.1303660

 

RNA-Seq Highlights High Clonal Variation in Monoclonal Antibody Producing CHO Cells

Orellana, Camila A. ; Marcellin, Esteban ; Palfreyman, Robin W. ; Munro, Trent P. ; Gray, Peter P. ; Nielsen, Lars Keld
in journal: Biotechnology Journal (ISSN: 1860-6768) (DOI: http://dx.doi.org/10.1002/biot.201700231), 2018

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2018     |    DOI: http://dx.doi.org/10.1002/biot.201700231

 

Multiplexed CRISPR/Cas9 Genome Editing and Gene Regulation Using Csy4 in Saccharomyces cerevisiae

Ferreira, Raphael ; Skrekas, Christos ; Nielsen, Jens ; David, Florian
in journal: A C S Synthetic Biology (ISSN: 2161-5063) (DOI: http://dx.doi.org/10.1021/acssynbio.7b00259), vol: 7, issue: 1, pages: 10-15, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1021/acssynbio.7b00259

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Expression of cocoa genes in Saccharomyces cerevisiae improves cocoa butter production

Wei, Yongjun ; Bergenholm, David ; Gossing, Michael ; Siewers, Verena ; Nielsen, Jens
in journal: Microbial Cell Factories (ISSN: 1475-2859) (DOI: http://dx.doi.org/10.1186/s12934-018-0866-2), vol: 17, issue: 1, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1186/s12934-018-0866-2

2017
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VARIANTS OF ACETYLSEROTONIN O-METHYLTRANSFERASE AND USES THEREOF

Luo, Hao (Inventor)
Patent no.: WO2017202897, Date: 30-11-2017

Type: Patent

Status: Published     |    Year: 2017

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Genome-wide analysis of E. coli cell-gene interactions

Cardinale, Stefano ; Cambray, G.
in journal: BMC Systems Biology (ISSN: 1752-0509) (DOI: http://dx.doi.org/10.1186/s12918-017-0494-1), vol: 11, issue: 1, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1186/s12918-017-0494-1

 

High throughput in vivo protease inhibitor selection platform

van der Helm, Eric (Inventor) ; Sommer, Morten Otto Alexander (Inventor)
Patent no.: WO2017186854, Date: 02-11-2017

Type: Patent

Status: Published     |    Year: 2017

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Engineered mammalian cells for production of recombinant proteins

Voldborg, Bjørn Gunnar (Inventor) ; Pedersen, Lasse Ebdrup (Inventor)
Patent no.: WO2017186671, Date: 02-11-2017

Type: Patent

Status: Published     |    Year: 2017

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Optimized microbial cells for production of melatonin and other compounds

Luo, Hao (Inventor) ; Förster, Jochen (Inventor)
Patent no.: WO2017167866, Date: 05-10-2017

Type: Patent

Status: Published     |    Year: 2017

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Improved biological processes for the production of aryl sulfates

Jendresen, Christian Bille (Inventor) ; Nielsen, Alex Toftgaard (Inventor)
Patent no.: WO2017144671, Date: 31-08-2017

Type: Patent

Status: Published     |    Year: 2017

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A family of microbial lysine transporter polypeptides

Malla, Sailesh (Inventor) ; Sommer, Morten Otto Alexander (Inventor) ; van der Helm, Eric ; Wieschalka, Stefan (Inventor) ; Förster, Jochen
Patent no.: WO2017085241, Date: 26-05-2017

Type: Patent

Status: Published     |    Year: 2017

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A system for improved production titers in fermentations

Rugbjerg, Peter (Inventor) ; Sarup-Lytzen, Kira (Inventor) ; Sommer, Morten Otto Alexander (Inventor)
Patent no.: WO2017055360, Date: 06-04-2017

Type: Patent

Status: Published     |    Year: 2017