Helene Faustrup Kildegaard

Helene Faustrup Kildegaard

Senior Researcher and Co-PI

DTU BIOSUSTAIN
Novo Nordisk Foundation Center for Biosustainability

CFB-S-CHO Cell Line Engineering And Design

Technical University of Denmark

Building 220, room 506F

2800 Kgs. Lyngby

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2017
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Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion

Beuchert Kallehauge, Thomas ; Li, Shangzhong ; Pedersen, Lasse Ebdrup ; Kwang Ha, Tae ; Ley, Daniel ; Andersen, Mikael Rørdam ; Kildegaard, Helene Faustrup ; Min Lee, Gyun ; Lewis, Nathan E.
in journal: Scientific Reports (ISSN: 2045-2322) (DOI: http://dx.doi.org/10.1038/srep40388), vol: 7, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1038/srep40388

 

Engineer medium and feed for modulating N-glycosylation of recombinant protein production in CHO cell culture

Fan, Yuzhou ; Kildegaard, Helene Faustrup ; Andersen, Mikael Rørdam
part of: Heterologous Protein Production in CHO cells, pages: 209-226, 2016, Springer,

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1007/978-1-4939-6972-2_14

 

Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

Hansen, Henning Gram ; Pristovsek, Nusa ; Kildegaard, Helene Faustrup ; Min Lee, Gyun
in journal: Biotechnology Advances (ISSN: 0734-9750) (DOI: http://dx.doi.org/10.1016/j.biotechadv.2016.11.008), vol: 35, issue: 1, pages: 64–76, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.biotechadv.2016.11.008

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Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data

Lund, Anne Mathilde ; Kaas, Christian Schrøder ; Brandl, Julian ; Pedersen, Lasse Ebdrup ; Kildegaard, Helene Faustrup ; Kristensen, Claus ; Andersen, Mikael Rørdam
in journal: B M C Systems Biology (ISSN: 1752-0509) (DOI: http://dx.doi.org/10.1186/s12918-017-0414-4), vol: 11, issue: 1, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1186/s12918-017-0414-4

 

Cell Factory Engineering

Davy, Anne Mathilde ; Kildegaard, Helene Faustrup ; Andersen, Mikael Rørdam
in journal: Cell Systems (ISSN: 2405-4712) (DOI: http://dx.doi.org/10.1016/j.cels.2017.02.010), vol: 4, issue: 3, pages: 262-275, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.cels.2017.02.010

 

Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells

Grav, Lise Marie ; Julie la Cour Karottki, Karen ; Lee, Jae Seong ; Kildegaard, Helene Faustrup
part of: Heterologous Protein Production in CHO cells, pages: 101-118, 2017, Springer,

Type: Book chapter (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1007/978-1-4939-6972-2_7

2016
 

Glycoprofiling effects of media additives on IgG produced by CHO cells in fed-batch bioreactors

Kildegaard, Helene Faustrup ; Fan, Yuzhou ; Wagtberg Sen, Jette ; Larsen, Bo ; Andersen, Mikael Rørdam
in journal: Biotechnology and Bioengineering (Print) (ISSN: 0006-3592) (DOI: http://dx.doi.org/10.1002/bit.25715), vol: 113, issue: 2, pages: 359-366, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1002/bit.25715

 

A Markov chain model for N-linked protein glycosylation – towards a low-parameter tool for model-driven glycoengineering

Spahn, Philipp N. ; Hansen, Anders Holmgaard ; Hansen, Henning Gram ; Arnsdorf, Johnny ; Kildegaard, Helene Faustrup ; Lewis, Nathan
in journal: Metabolic Engineering (ISSN: 1096-7176) (DOI: http://dx.doi.org/10.1016/j.ymben.2015.10.007), vol: 33, pages: 52-66, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1016/j.ymben.2015.10.007

 

Accelerated Homology-Directed Targeted Integration of Transgenes in Chinese Hamster Ovary Cells Via CRISPR/Cas9 and Fluorescent Enrichment

Lee, Jae Seong ; Grav, Lise Marie ; Pedersen, Lasse Ebdrup ; Min Lee, Gyun ; Kildegaard, Helene Faustrup
in journal: Biotechnology and Bioengineering (Print) (ISSN: 0006-3592) (DOI: http://dx.doi.org/10.1002/bit.26002), vol: 113, issue: 11, pages: 2518-2523, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1002/bit.26002

 

Endoplasmic reticulum-directed recombinant mRNA displays subcellular localization equal to endogenous mRNA during transient expression in CHO cells

Beuchert Kallehauge, Thomas ; Kol, Stefan ; Andersen, Mikael Rørdam ; Kroun Damgaard, Christian ; Min Lee, Gyun ; Kildegaard, Helene Faustrup
in journal: Biotechnology Journal (ISSN: 1860-6768) (DOI: http://dx.doi.org/10.1002/biot.201600347), vol: 11, issue: 10, pages: 1362-1367, 2016

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2016     |    DOI: http://dx.doi.org/10.1002/biot.201600347


http://www.biosustain.dtu.dk/english/publications/person?id=21885&tab=2&qt=dtupublicationquery
23 SEPTEMBER 2017