PhD scholarship for A detailed kinetic description of the Warburg Effect

Center for Biosustainability
Thursday 07 Jun 18

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We are seeking outstanding candidates for a 4-year fully funded Ph.D-scholarship to join the Novo Nordisk Foundation for Biosustainability, Technical University of Denmark, and be part of the Quantitative Modelling of Cell Metabolism research unit led by Lars Nielsen.

Responsibilities and tasks
The candidate will research the Warburg effect in mammalian cells using kinetic modelling techniques. Work will be alongside a group of scientists focused on Omics integration, network reconstruction, and statistical analysis. The overall goal of the unit is to study homeostasis in cells.

Qualifications
Candidates should have a master's degree in engineering or a similar degree with an academic level equivalent to the master's degree in engineering.

Preference will be given to candidates with:
The ideal candidate will have a B.Eng./M.Sc. degree in biological engineering or similar and have achieved outstanding results in their education. Model reconstruction experience is an advantage as well as scientific publications.

Approval and Enrolment
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.

Assessment
In the assessment of the candidates consideration will be given to grade marks during their education, primarily with their end of degree thesis. Previous experimental and computational work will be reviewed.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 4 years.

You can read more about career paths at DTU here.

Workplace
Workplace will be at DTU, Kemitorvet, Building 220, 2800 Lyngby.

Further information
Further information may be obtained from Scientific Director Lars Keld Nielsen lakeni@biosustain.dtu.dk

You can read more about the Quantitative Modelling of Cell Metabolism research unit on http://www.biosustain.dtu.dk/english/research/scientific-sections/quantitative-modelling-of-cell-metabolism

Please do not send applications to this e-mail address, instead apply online as described below.

Application
Please submit your online application no later than 31 June 2018 (local time). Apply online at www.career.dtu.dk.

Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link "Apply online", fill in the online application form, and attach all your materials in English in one pdf file. The file must include:
  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma (an official translation into English)
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here)

Candidates may apply prior to obtaining their master's degree, but cannot begin before having received it.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

At the Quantitative Modelling of Cell Metabolism unit, we focus on developing mathematical models to explore and explain the molecular basis for homeostasis – the self-regulating processes evolved to maintain metabolic equilibrium.
Studying homeostasis is relevant for the understanding and treatment of complex diseases, particular with the emergence of personalized medicine.

It is equally important when we seek to repurpose the cellular machinery for the production of desired chemicals, materials and pharmaceuticals. In this process, the cells’ homeostatic control mechanisms must be either disabled or exploited.
Cellular reactions are catalyzed by enzymes. In order to model homeostasis, we need to model the kinetics of all the enzymes involved in cellular metabolism and the regulation of their expression.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.

 

http://www.biosustain.dtu.dk/english/about/job/job?id=04a00990-76af-459b-b064-af17ce3dcc86
22 JUNE 2018