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Core Flow

 

Core - Translational Research Unit

 

The Core  of the center performs translational research in a company management structure format. This implies a management team and operation as a unit that can effectively interact with commercial concerns and spin-out new companies.

 

The CFB is centered on the development of the computational and experimental technologies that enable the Core workflow and its iterative loop to flow as smoothly as possible and in an balanced fasion to avois bottlenecks in the process. The technological drivers for the Core can be grouped into roughly four categories:

 

Bioanalytics

  • Molecular biology toolboxes
  • Genome-scale in silico models
  • High througput screening

These technologies will drive and hone the the iterative design loop and accelerate the the generation of both production and platform strains, thus significantly advancing the overall goal of CFB. 

 

The CFB currently has 13 ongoing translational research projects. These projects have an applied emphasis, a variable duration of 12-24 months, and can be rapidly terminated and initiated, as is typical for a company setting. The data and IT department have a permanent function. Each project is headed by an experienced researcher at a high international level and some with notable experience from industry.

 

Present projects include:

Bioprocess & Strain Development

 

·         Metabolic Engineering for 3HP – Dr. Irina Borodina

 

·         Functional Food Additives – Prof. Alex T. Nielsen

 

·         Human Molecules – Prof. Jochen Förster

 

·         Industrial Platform Strain Development – Prof. Förster/Dr. Herrgard

 

·         Metabolic Engineering of Flavonoids – Dr. Ana Rute Neves

 

·         Sustainable production of cyclic triterpenes using specialized baker’s yeast – Dr. Jerome Maury

 

 

Technology Development

 

·         Multiplex Automated Genome Engineering – Prof. Morten Sommer

 

·         Microbial Electrosynthesis – Dr. Karsten Zengler

 

·         P450 Platform Strain – Dr. Morten Nørholm

 

·         Adaptive Laboratory Evolution – Dr. Adam Feist

 

 

Data and IT Infrastructure Departments

 

·         Modeling and Systems Biology Department – Dr. Markus Herrgard

 

·         Analytics Department –Dr. Scott Harrison

 

 

CHO Cell Line Project Portfolio  - Bjørn Voldborg

 

·         Cell Strain Construction Pipeline

·         Media and Bioprocess Optimization

·         Protein Purification

 

Laboratory Management – Fredrik Lindqvist

 

 



 

 

Last updated 20.12.2012
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